went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
#semaglutide 2025-04-26
Saturday61 messages14 participantstimes are UTC
Highlights from this day
- verify_or_dont — moving my dose day by a day or two never did anything noticeable for me 17:50
- VialBot — Verification log updated: TFC — evidence added, status unchanged. 17:52
- step_one_sian — brand vs compounded, is there a difference people can actually feel 18:34
- swab_dry_first — im at 1.7 and stuck, did anyone break a plateau without going up 19:09
i dont think the plateau is a dose problem most of the time, but i cant prove that
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, still working it out
not the same trial
follow up my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
thats STEP 1
Purity check: no report on file for lot D-0718. Nothing logged either way.
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, someone check my working
does the seven day half life mean the last two days are weaker
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five week steps worked better for me than four, purely on how the second week felt
did anybody find a difference between BCH and pharmacy at the same 5
went too fast once
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lost about 22kg on the low doses before i even got to 1, which surprised me
plateaus move
same dose day
does the licensed ceiling for weight differ from the diabetes one
how long did the first 29kg take for people at the low doses
moving my dose day by a day or two never did anything noticeable for me
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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Verification log updated: TFC — evidence added, status unchanged.
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how did people handle the jump from 1 to 1.7
dose day is sunday for me only because thats when i remember, not because sunday matters
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is there a reason to hold at 1.7 rather than going to 2.4
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does anyone actually run a five week step instead of four
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back after 14 months off, do i restart at 0.25 or somewhere higher
half life is about a week so youre roughly four to five weeks to steady state on any new dose, n of 1 obviously
2.4 is the ceiling
anyone compared their 2 vial dosing against the pen increments
anyone gone from 12 straight to 2.4 or is that too big a jump
brand vs compounded, is there a difference people can actually feel
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im 6 months in at 10 and the appetite effect faded, is that a thing
[edited]going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, i have it written down somewhere
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
give it four weeks
i held at 0.5 for 8 months and it was the best decision i made
how many weeks before you noticed anything at 2.4
im at 1.7 and stuck, did anyone break a plateau without going up
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sorry to jump in how long till steady state, ive read the half life is about a week
held at 1.7 and lost 78lb over 16 months, slower than the trials and fine by me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, ask me again in a month
did anyone hold at 0.25 longer than four weeks before going up
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is the plateau usually appetite coming back or just the scale stopping
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
does moving my dose day by two days matter with a seven day half life
15 months at 2.4 and the honest summary is diminishing returns after the first half
is 2.4 the top or do people go past it
the plateau hit me at 20 weeks and moved again about a month later without a dose change
coming back to this did anyone titrate slower than four weeks a step and how did that go
*week 28 not week 9
i stayed on 1.7 for 20 months and never went to 2.4, appetite was already where i needed it
is the plateau at 24 weeks normal or am i doing something wrong
slower worked better
my 30 vial in 1ml gives 5mg/ml so 0.5 lands on 12 units, thats why i picked that volume
my Medutest report on the JEEP vial came back 99.4 against a certificate saying 99
[edited]what did SELECT actually measure, i see it quoted for everything
did the STEP 4 withdrawal arm show what i think it showed
seven days ish