right so SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
#tirzepatide 2025-04-28
Monday48 messages9 participantstimes are UTC
Highlights from this day
- appetite_back — at 7.5 my appetite is gone entirely, did anyone go down rather than up 18:55
- pooled_sample — whats the plateau pattern here, same as semaglutide or different 19:44
- split_dose_sam — coming back to this 40 units of a 10 solution is a lot of volume and i check that one twice every single time 12 did nothing extra over 10 for me and that still holds… 20:49
- split_dose_sam — is the sweet spot argument about effect or about side effects 21:31
- appetite_back — if youre coming off semaglutide the honest answer is start low and find out, theres no table 22:26
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 7.5 my appetite is gone entirely, did anyone go down rather than up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
there is no clean conversion between the two, anyone giving you a ratio is guessing
is SURMOUNT-OSA the sleep apnoea one
GIP plus GLP-1
coming off semaglutide, is there a conversion or do i restart at 2.5
[edited]for the archive my PeptideMeter result on a SSA vial came in at 99.4 which is why i keep buying from them
did anybody switch back to semaglutide after trying this
no gap when i switched, took the last semaglutide dose and started this a week later
no clean conversion
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the 20 vial in 1.5ml gives 5mg/ml which puts 15 on 5 units, nice round numbers
whats the plateau pattern here, same as semaglutide or different
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SURMOUNT is weight
[edited]the GI difference held for me right up to 15, which isnt what a couple of people here found
restarted at 2.5 after 7 months off and the first two doses reminded me why titration exists
does switching from semaglutide need a gap or do you just start
unrelated but the sweet spot argument is really about effect per side effect, not a magic number, not advice obviously
the switch felt like a step down at first and then caught up around week 3
5 did nothing
folklore probably
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at 15 the GI came back for me, so my easier profile claim only applies below that
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
the switch felt like a step down at first and then caught up around week 16
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
15 is the top
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
10 was enough
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coming back to this 40 units of a 10 solution is a lot of volume and i check that one twice every single time
12 did nothing extra over 10 for me and that still holds a year later
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i went to 15 and came back to 10, more suppression wasnt more useful for me
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titrate slow
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
12 did nothing extra over 10 for me and that still holds a year later, not advice obviously
changed my mind about needing 15, i was chasing a number rather than an outcome
went back to semaglutide after 10 months because the cost difference mattered more than the GI
is there a reason to titrate slower than the four week schedule
im at 1 and thinking about 2.5, did anyone gain anything from that step
whats the top licensed dose, 15 or does it go higher
is the sweet spot argument about effect or about side effects
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same plateau here
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
held 10 for 3 months and lost 42kg over that stretch, slow and boring and fine
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easier gi for me
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£38 for a 40 vial is roughly what ive paid for the last year
*PeptideMeter not the other one
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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does the GIP arm actually explain the easier nausea or is that hand waving
does the appetite effect feel different or just stronger