back after 5 months off, do i restart at 0.25 or somewhere higher
#semaglutide 2025-05-01
Thursday55 messages10 participantstimes are UTC
Highlights from this day
- half_life_hal — im 19 months in at 7.5 and the appetite effect faded, is that a thing 19:43
- verify_or_dont — was SURPASS-2 the one that ran to 68 weeks or am i mixing them up 19:56
- ten_of_ten — STEP is several trials, so saying STEP said x is usually wrong without a number after it 19:59
- ten_of_ten — brand vs compounded, is there a difference people can actually feel 20:06
im at 2.5 and stuck, did anyone break a plateau without going up
slightly off topic but how long till steady state, ive read the half life is about a week
moving my dose day by a day or two never did anything noticeable for me, anyway
dose day is sunday for me only because thats when i remember, not because sunday matters
i dont think the plateau is a dose problem most of the time, but i cant prove that, anyway
seven days ish
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
while im here 9 months at 2.4 and the honest summary is diminishing returns after the first half
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
thats STEP 1
does the seven day half life mean the last two days are weaker
how many weeks before you noticed anything at 2.4
vials not pens here
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five week steps worked better for me than four, purely on how the second week felt
plateaus move
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
is the plateau at 3 weeks normal or am i doing something wrong
is there a reason to hold at 1.7 rather than going to 2.4
$38 a month for compounded against what brand costs locally is why most people here use vials
my PeptideMeter report on the ERP vial came back 98.6 against a certificate saying 99.2, thats one data point
update on the earlier thing half life is about a week so youre roughly four to five weeks to steady state on any new dose
im 19 months in at 7.5 and the appetite effect faded, is that a thing
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
held at 0.5 and lost 16lb over 12 months, slower than the trials and fine by me
went too fast once
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
brand vs compounded, is there a difference people can actually feel
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SELECT wasnt weight
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi held at 0.5 for 4 months and it was the best decision i made
my 5 vial in 1ml gives 10mg/ml so 2.5 lands on 5 units, thats why i picked that volume
while im here whats the actual licensed ceiling, i keep seeing different numbers
same dose day
slower worked better
mine faded too
held there too
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
did anyone hold at 5 longer than four weeks before going up
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the appetite effect faded for me around 17 months and going up fixed it for a while
STEP 1 ran to 68 weeks. thats the one everyone half remembers
for the archive went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
verify_or_dontmy 5 vial in 1ml gives 10mg/ml so 2.5 lands on 5 units, thats why i picked that volume
i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it
the plateau hit me at 19 weeks and moved again about a month later without a dose change
is 2.4 the top or do people go past it
thats STEP 1
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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steady state takes weeks
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give it four weeks
anyone compared their 2.5 vial dosing against the pen increments
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
slightly off topic but dose day is sunday for me only because thats when i remember, not because sunday matters
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
not the same trial
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how did people handle the jump from 1 to 1.7
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution