Fortnightly digest · 2024-09-23 → 2024-10-06
the kidney result, read properly, by people who read it properly
A major renal outcome trial published this year finally got a careful reading rather than a headline. The channel that did it was bloodwork rather than semaglutide, which tells you something about where the room keeps its rigour. Two members with reduced kidney function had questions that nobody in a chat room can answer, and were told exactly that, kindly.
1.6Kmessages
78day logs
3channels noted
5notes
What happened
- FLOW in NEJM 2024 was read for what it studied and what it did not, and the distinction between a trial population and a chat room was made explicitly.
- eGFR trajectory rather than a single reading was the point several members had been missing when comparing results a year apart.
- Nobody in the channel pretended a renal endpoint in a monitored trial translates into a recommendation for a member with existing disease.
- The baseline panel pin was updated to make the renal function line harder to skip past, which it had been for about eight months.
- A member with an isolated raised lipase was talked through what that does and does not indicate, with the red-flag symptom list restated in full.
Channels this fortnight
#bloodworkBaseline panels, A1c lag, apoB, lipase, eGFR. Bring the actual numbers.2 logs · 51 msgs#semaglutideSemaglutide. STEP and SELECT data, 0.25 to 2.4mg, and what happens above it.7 logs · 162 msgs#side-effectsNausea, constipation, the month-four shed, and when to stop reading chat and see somebody.7 logs · 153 msgs
Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
taper_tesscoming back after 8 months with a follow up result, where do i put it51 reactions · #test-results · 2024-09-29lot_number_loumy first order from GL Biochem was fine and my fourth was better. they have improved44 reactions · #vendor-talk · 2024-09-28quiet.hourssorry to jump in is monoisotopic or average mass the one on most certificates44 reactions · #hplc-massspec · 2024-09-29night_pinlet the alcohol dry. that is ninety percent of "my injections sting"41 reactions · #injection-technique · 2024-09-29taper_tessanyone here split their weekly into two and would they do it again37 reactions · #dosing-titration · 2024-09-25week_three_walldont push through36 reactions · #side-effects · 2024-09-26one_variablewhats a sensible maintenance dose after a year at treatment dose34 reactions · #dosing-titration · 2024-09-25hair_month_fourthe GIP explanation for easier nausea is plausible and i still treat it as a story not a fact33 reactions · #tirzepatide · 2024-10-01
Busiest logs in this fortnight
#dosing-titration · 2024-09-29i would hold47 msgs#dosing-titration · 2024-09-30i went up too fast and im paying for it, do i drop back or ride it out40 msgs#tirzepatide · 2024-10-04plateaued at 21 weeks the same way i did on semaglutide, so i doubt its compound specific40 msgs#off-topic · 2024-10-05what is everyone drinking now that alcohol has stopped being fun38 msgs#dosing-titration · 2024-09-25n of 136 msgs#side-effects · 2024-10-03unrelated but escalation is when most of the trouble happens, not the absolute dose, still working it out33 msgs#semaglutide · 2024-10-06plateaus move33 msgs#wins · 2024-10-06half a stone in 26 weeks sounds slow written down and felt enormous while it was happening33 msgs#vendor-talk · 2024-09-28per mg including shipping32 msgs#vendor-talk · 2024-09-29the same 50mg at 185 with free shipping is 3.70 per mg. cheaper, and i still ordered the first one32 msgs#oral-glp1 · 2024-10-03while im here the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most…32 msgs#test-results · 2024-10-03whats the underfill rate people are actually seeing31 msgs