#dosing-titration 2024-09-28

Saturday21 messages7 participantstimes are UTC

Highlights from this day

first_and_last_four — nobody here can tell you what dose to be on and the ones who try get corrected plateau versus set point is not answerable in under six months of data 23:08
salt_bridge — if the current dose is still working, going up is spending headroom you might want later, still working it out 23:33
taper_tess — genuine question has anyone gone up and then straight back down and been glad they tried 23:42
monoisotopic — i hold for two months minimum before i decide a dose has stopped doing anything, ymmv 23:52

nobody here can tell you what dose to be on and the ones who try get corrected
plateau versus set point is not answerable in under six months of data

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appetite returning at the end of the week is extremely common and is not the dose failing

the people who do best here are almost always the ones going slowest, ymmv

pick a day and stick to it

my titration ladder took 22 months to climb and i would do it slower again

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, we shall see

split dosing has no trial behind it. people here do it and report on it, thats all

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, take that with a pinch of salt

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came down, no regrets

if it "stopped working after four days" that is almost never pharmacokinetics

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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

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too early imo

if the current dose is still working, going up is spending headroom you might want later, still working it out

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right so is week 7 too early to be thinking about the next step

[edited]

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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

small steps are better than big ones and the only reason people take big ones is impatience

genuine question has anyone gone up and then straight back down and been glad they tried

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

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plateau versus set point is not answerable in under six months of data

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follow up if you are asking whether to go up, the fact you are asking usually means not yet, n of 1 obviously

you do not have to escalate at all. that is a real option that gets forgotten

i hold for two months minimum before i decide a dose has stopped doing anything, ymmv

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