i went up too fast and im paying for it, do i drop back or ride it out
weights-monthly.csv
823 rows · not retained in the public archive
#dosing-titration 2024-09-30
Monday40 messages10 participantstimes are UTC
Highlights from this day
no trial for that
i hold for two months minimum before i decide a dose has stopped doing anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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steady state is 5 weeks
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
came down from a treatment dose to maintenance over about three months and it was uneventful
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what does the room think about jumping a rung to catch up
if it "stopped working after four days" that is almost never pharmacokinetics
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if you are asking whether to go up, the fact you are asking usually means not yet
i would hold
16:38tenpence pinned a message
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, ill dig out the number
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
has anyone gone up and then straight back down and been glad they tried
New independent result logged — MKM, lot SG-1177, purity 98.1% (Janoshik).
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came down, no regrets
the honest answer is that most of us are running protocols nobody has ever studied
hold
coming down from 0.5 to 12, how bad is the appetite rebound
go slower
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
is there a point where going up stops buying you anything
thats noise
my titration ladder took 17 months to climb and i would do it slower again
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too early imo
the ladder in the trials is a starting point, not a schedule you owe anyone, anyway
n of 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
half life is a week
nobody here can tell you what dose to be on and the ones who try get corrected
sorry to jump in the trials escalated on a fixed schedule because a trial has to. you are not a trial
appetite returning at the end of the week is extremely common and is not the dose failing
thats anecdote
with a roughly seven day half-life you are near steady state after about five weeks at a dose
how long did you hold at 2.4 before you moved up
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if i hold at 12 indefinitely am i losing anything
held for months
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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*that should say weekly