Fortnightly digest · 2025-09-08 → 2025-09-21
cardiovascular outcomes, and what the room does with an endpoint
A cardiovascular outcomes trial got a proper reading in the bloodwork channel, which by now is where the room does its careful work. The interesting argument was not about the result but about what a member with no cardiovascular disease should take from a secondary-prevention population. The honest answer, arrived at slowly, is not very much.
6.3Kmessages
239day logs
3channels noted
5notes
What happened
- SELECT in NEJM 2023 was read for its population as much as its endpoint, and the distinction did most of the work in the conversation.
- A secondary-prevention result does not transfer cleanly to a member with no established disease, which several people wanted it to.
- apoB versus LDL cholesterol came up again and this time produced a practical suggestion, which is to track whichever one you can get repeatedly.
- STEP 2 in Lancet 2021 was brought in by a member with type 2 diabetes who wanted the trial that actually studied people like them.
- Two members posted twelve-month lipid panels side by side and the difference in what improved was a useful corrective to any single story.
Channels this fortnight
#bloodworkBaseline panels, A1c lag, apoB, lipase, eGFR. Bring the actual numbers.7 logs · 131 msgs#semaglutideSemaglutide. STEP and SELECT data, 0.25 to 2.4mg, and what happens above it.10 logs · 370 msgs#winsScale and non-scale. Rings, stairs, CPAP pressures, A1c. All of it counts.11 logs · 298 msgs
Sponsored · paired placement
Direct manufacturerGL Biochem (Shanghai) Ltd. — the synthesis houseFounded 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. A great deal of what gets sent for testing was made here first. Custom synthesis quoted to small orders.Browse GL Biochem →Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
escalation_anxietyselection bias49 reactions · #test-results · 2025-09-14yyz_vialeverybody i have seen stop and hold it did something else as well, without exception in my time here47 reactions · #maintenance · 2025-09-14rezept_rolfthe price for the same dose in two eu countries differed by about forty percent in the one careful comparison i have seen in here,…46 reactions · #eu · 2025-09-10back_from_awaySURPASS-2 is the stopping one. weight came back on for most people once the drug stopped. that is the finding, not an opinion46 reactions · #maintenance · 2025-09-12oasis_olai log the fridge temperature daily and the room has never let me forget it44 reactions · #storage-coldchain · 2025-09-16comment_fatiguehand luggage43 reactions · #storage-coldchain · 2025-09-21seoul_swirlif you are asking whether to go up, the fact you are asking usually means not yet41 reactions · #dosing-titration · 2025-09-14fake_trackingrotate the site41 reactions · #side-effects · 2025-09-20
Busiest logs in this fortnight
#tirzepatide · 2025-09-14licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, i…65 msgs#dosing-titration · 2025-09-14has anyone gone up and then straight back down and been glad they tried65 msgs#semaglutide · 2025-09-16im at 1.7 and stuck, did anyone break a plateau without going up62 msgs#semaglutide · 2025-09-18sorry to jump in i dont think the plateau is a dose problem most of the time, but i cant prove that61 msgs#vendor-talk · 2025-09-21my first order from FGP was fine and my fourth was better. they have improved59 msgs#test-results · 2025-09-14my result contradicts the supplier certificate, do i tell them58 msgs#tirzepatide · 2025-09-20at 15 the GI came back for me, so my easier profile claim only applies below that58 msgs#tirzepatide · 2025-09-12GIP plus GLP-157 msgs#test-results · 2025-09-21ok so a result without a lot number and a purchase date is an anecdote with a pdf attached57 msgs#dosing-titration · 2025-09-16coming back to this update question: did anyone who held for 16 months regret it56 msgs#semaglutide · 2025-09-14£38 a month for compounded against what brand costs locally is why most people here use vials55 msgs#tirzepatide · 2025-09-1615 is the top54 msgs