im at 1.7 and stuck, did anyone break a plateau without going up
#semaglutide 2025-09-16
Tuesday62 messages13 participantstimes are UTC
Highlights from this day
- appetite_back — changed my mind on the four week rule, i think it depends entirely on how the current dose feels, someone check my working 21:58
- pioneer_pia — did anyone titrate slower than four weeks a step and how did that go 22:14
- alt_ast_ali — brand vs compounded, is there a difference people can actually feel 22:38
- apob_over_ldl — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 23:09
- dog_person_dev — the appetite effect faded for me around 12 months and going up fixed it for a while, n of 1 obviously if youre comparing brand to compounded, dose accuracy in the… 23:54
thats STEP 1
vials not pens here
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how did people handle the jump from 1 to 1.7
seven days ish
Purity check: no report on file for lot A-2418. Nothing logged either way.
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, still working it out
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slower worked better
not the same trial
SELECT wasnt weight
held at 0.25 and lost 84lb over 21 months, slower than the trials and fine by me
give it four weeks
restarted after 7 months off at a low dose and the nausea arrived exactly like the first time
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
vial units and pen clicks are different systems, mixing the two is how people end up wrong
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, someone check my working
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does the seven day half life mean the last two days are weaker
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, i could be wrong
is the plateau usually appetite coming back or just the scale stopping
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
my PeptideMeter report on the BCH vial came back 97.4 against a certificate saying 99.2
$120 a month for compounded against what brand costs locally is why most people here use vials, anyway
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
back after 18 months off, do i restart at 0.25 or somewhere higher
did anyone titrate slower than four weeks a step and how did that go
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compounded and brand felt the same to me at 0.5, which is one person and nothing more
STEP is several trials, so saying STEP said x is usually wrong without a number after it
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
follow up 10 months at 2.4 and the honest summary is diminishing returns after the first half
did anyone hold at 7.5 longer than four weeks before going up
my dose day drifted from friday to sunday, does that reset anything
what did SELECT actually measure, i see it quoted for everything
how long till steady state, ive read the half life is about a week
plateaus move
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
brand vs compounded, is there a difference people can actually feel
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steady state takes weeks
same dose day
im 7 months in at 5 and the appetite effect faded, is that a thing
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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mine faded too
went too fast once
[edited]wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggoing slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
held there too
is 2.4 the top or do people go past it
anyone gone from 1.7 straight to 5 or is that too big a jump
lost about 26kg on the low doses before i even got to 1, which surprised me
does moving my dose day by two days matter with a seven day half life
i stayed on 1.7 for 7 months and never went to 2.4, appetite was already where i needed it, n of 1 obviously
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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the plateau hit me at 20 weeks and moved again about a month later without a dose change, anyway
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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courier_vs_posthalf life is about a week so youre roughly four to five weeks to steady state on any…
the long half life flattens the trough more than people expect, i never felt a day seven dip
coming back to this i dont think the plateau is a dose problem most of the time, but i cant prove that
dose day is sunday for me only because thats when i remember, not because sunday matters
sorry to jump in anyone compared their 4 vial dosing against the pen increments
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did the STEP 4 withdrawal arm show what i think it showed
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
my 15 vial in 2.5ml gives 2.5mg/ml so 12 lands on 5 units, thats why i picked that volume
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe appetite effect faded for me around 12 months and going up fixed it for a while, n of 1 obviously
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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