Fortnightly digest · 2024-02-12 → 2024-02-25
the lead times start stretching and everyone pretends to be surprised
February did what February does. Quoted lead times moved from ten days to three weeks across most of the sourcing channel, and the people who had been here a year said the same thing they said last year, in the same tone. Two suppliers posted holiday notices in good time. Several members had clearly not read them.
495messages
24day logs
3channels noted
5notes
What happened
- GL Biochem and Sangon Biotech both went into holiday shutdown with notice, and the notice was still a surprise to about a third of the channel.
- The oral GLP-1 channel opened and spent its first week on why oral semaglutide bioavailability is roughly one percent and what SNAC is doing about it.
- The plain-water rule for oral dosing was restated three times because coffee keeps counting as something, no matter how much anyone wants it not to.
- Members were reminded that a holiday shutdown is a shutdown, not a supplier going quiet on them, and that the two look identical from outside.
- cold_chain_cmdr started a list of who had actually posted dates, which became the first version of a table the room still keeps.
Channels this fortnight
#vendor-talkSupplier experience. Price per mg, lead time, communication, fill consistency.2 logs · 46 msgs#oral-glp1Oral semaglutide, SNAC absorption, orforglipron and the non-peptide orals.0 logs · 0 msgs#shipping-customsTransit times, declared value, seizure letters, cold packs that arrive warm.0 logs · 0 msgs
Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
mg_per_mlright so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing36 reactions · #semaglutide · 2024-02-18LC_MS_Lenahow many weeks before you noticed anything at 1235 reactions · #semaglutide · 2024-02-13blind_submitnobody here gets paid to say anything about any supplier and the mods would end me if i did33 reactions · #vendor-talk · 2024-02-21mg_per_mlslightly off topic but STEP 1 ran to 68 weeks. thats the one everyone half remembers32 reactions · #semaglutide · 2024-02-23vialkeeperlost about 47kg on the low doses before i even got to 1, which surprised me30 reactions · #semaglutide · 2024-02-18u100_patcoming down from 1.7 to 1, how bad is the appetite rebound29 reactions · #dosing-titration · 2024-02-25lot_number_loudo you tell your prescriber about the small stuff or only the big stuff28 reactions · #side-effects · 2024-02-21chlorhexfive week steps worked better for me than four, purely on how the second week felt, thats just me25 reactions · #semaglutide · 2024-02-15
Busiest logs in this fortnight
#side-effects · 2024-02-24hope it settles36 msgs#dosing-titration · 2024-02-25steady state is 5 weeks33 msgs#semaglutide · 2024-02-17the appetite effect faded for me around 12 months and going up fixed it for a while31 msgs#side-effects · 2024-02-21coming back after 4 months off: do the side effects reset29 msgs#semaglutide · 2024-02-23not the same trial29 msgs#tirzepatide · 2024-02-19the GI difference held for me right up to 15, which isnt what a couple of people here found went back to…28 msgs#vendor-talk · 2024-02-21ask who makes it28 msgs#semaglutide · 2024-02-16does the seven day half life mean the last two days are weaker27 msgs#dosing-titration · 2024-02-15Verification log updated: GGPeps — evidence added, status unchanged.26 msgs#other-peptides · 2024-02-17one thing at a time25 msgs#side-effects · 2024-02-15water first, then fibre, then magnesium, then a softener, then a pharmacist. in that order24 msgs#semaglutide · 2024-02-18vial units and pen clicks are different systems, mixing the two is how people end up wrong i held at 0.5…24 msgs