does the seven day half life mean the last two days are weaker
#semaglutide 2024-02-16
Friday27 messages8 participantstimes are UTC
Highlights from this day
- HPLC_Hank — im at 1 and stuck, did anyone break a plateau without going up 18:42
- deadspace — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial i stayed on 1.7 for 18 months and never went to 2.4, appetite… 18:43
- ferrous_ash — does the licensed ceiling for weight differ from the diabetes one 22:08
im at 1 and stuck, did anyone break a plateau without going up
✅1😂11
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
$120 a month for compounded against what brand costs locally is why most people here use vials, your mileage will differ
thats STEP 1
compounded and brand felt the same to me at 10, which is one person and nothing more
😂5
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
❤️3🔥3
plateaus move
❤️10🙏1🧪4
slower worked better
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi dont think the plateau is a dose problem most of the time, but i cant prove that
my dose day drifted from friday to sunday, does that reset anything
quick one whats the actual licensed ceiling, i keep seeing different numbers
steady state takes weeks
is the plateau at 15 weeks normal or am i doing something wrong
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
anyone gone from 10 straight to 12 or is that too big a jump
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
vials not pens here
coming back to this back after 1 months off, do i restart at 0.25 or somewhere higher
half life is about a week so youre roughly four to five weeks to steady state on any new dose
does anyone actually run a five week step instead of four
not the same trial
held there too
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time
does the licensed ceiling for weight differ from the diabetes one
🤝11
seven days ish
while im here what did SELECT actually measure, i see it quoted for everything