steady state is 5 weeks
#dosing-titration 2024-02-25
Sunday33 messages8 participantstimes are UTC
Highlights from this day
- HPLC_Hank — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, someone check my working 18:35
- HPLC_Hank — the trials escalated on a fixed schedule because a trial has to. you are not a trial, someone check my working 18:40
- u100_pat — coming down from 1.7 to 1, how bad is the appetite rebound 20:36
- deadspace — follow up i went up too fast and im paying for it, do i drop back or ride it out 21:13
- bea_reconstitutes — do you escalate on the calendar or on how you feel 22:09
i drifted from sunday to wednesday over a year and only noticed when i checked the log
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, someone check my working
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thats anecdote
the trials escalated on a fixed schedule because a trial has to. you are not a trial, someone check my working
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n of 1
not advice
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, n of 1 obviously
how long did you hold at 7.5 before you moved up
no trial for that
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*that should say weekly
does a missed week reset anything or do you just carry on
half life is a week
came down from a treatment dose to maintenance over about three months and it was uneventful
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hold
whats the smallest step anyone has managed between doses
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
the honest answer is that most of us are running protocols nobody has ever studied, we shall see
came down, no regrets
nobody here can tell you what dose to be on and the ones who try get corrected
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how do you tell a plateau from just being at your set point
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ask me again in a month
update from 23 months ago: held at the same dose the whole time and still losing slowly
coming down from 1.7 to 1, how bad is the appetite rebound
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whats your rule for when a side effect means hold rather than push
my titration ladder took 22 months to climb and i would do it slower again
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
with a roughly seven day half-life you are near steady state after about five weeks at a dose
follow up i went up too fast and im paying for it, do i drop back or ride it out
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you do not have to escalate at all. that is a real option that gets forgotten, i have it written down somewhere
anyone tracked whether a smaller more frequent dose changed their side effects
do you escalate on the calendar or on how you feel
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end of week thing
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else