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#tirzepatide 2025-03-19

Wednesday30 messages8 participantstimes are UTC
Highlights from this day
  • luerlok — i sat at 7.5 for 4 months and never needed more, which is where the folklore comes from 14:46
  • surpass_two — 12 did nothing extra over 10 for me and that still holds a year later, ask me again in a month 16:41
  • VialBot — Channel stats, last 30 days: 89 messages from 50 members. 17:33
ST

did anyone find the GI easier than semaglutide at an equivalent effect

LU

i sat at 7.5 for 4 months and never needed more, which is where the folklore comes from

🧪13💀7
TD

i log everything and my appetite curve looks flatter across the week than my semaglutide log did, your mileage will differ

13📈1

slightly off topic but the switch felt like a step down at first and then caught up around week 15

TD

did anybody switch back to semaglutide after trying this
plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific

ST

plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific

RR

coming off semaglutide, is there a conversion or do i restart at 2.5

[edited]
ST

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

TD

right so at 0.25 my appetite is gone entirely, did anyone go down rather than up

2👀5🔥2
ST

12 did nothing extra over 10 for me and that still holds a year later, ask me again in a month

⚠️12🎉3
TD

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

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VB

Channel stats, last 30 days: 89 messages from 50 members.

⚠️17📈15
NF

the two compounds arent interchangeable week for week even if the effect ends up similar

NF

does the appetite effect feel different or just stronger

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.
TD

did going from 15 semaglutide to 5 of this feel like a step down for anyone
i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from

OW

coming back to this the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

OW

quick one at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win

OW

at 15 the GI came back for me, so my easier profile claim only applies below that

7.5 gang