#tirzepatide 2025-03-18

Tuesday35 messages11 participantstimes are UTC

Highlights from this day

lean_mass_lex — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 18:22
lean_mass_lex — right so is 7.5 really the sweet spot or is that just channel folklore dual agonist, GIP as well as GLP-1, thats the whole difference in one line 18:24
thirty_min_wait — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 19:56
ring_size_down — does the appetite effect feel different or just stronger 21:00
seven_five_sweet — if youre coming off semaglutide the honest answer is start low and find out, theres no table 21:27

lean_mass_lex 18:11

i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more

lean_mass_lex 18:21

how many weeks at 7.5 before you knew it was enough

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

😂16🔥6📈10

right so is 7.5 really the sweet spot or is that just channel folklore
dual agonist, GIP as well as GLP-1, thats the whole difference in one line

🎉11👀11

dexa_or_bia 18:25

GIP plus GLP-1

a1c_lag 18:26

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

a1c_lag 18:37

at 15 the GI came back for me, so my easier profile claim only applies below that

VialBotbot18:48

New independent result logged — ERP, lot F-1330, purity 99% (PeptideMeter).

warsaw_vial 18:54

for the archive the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, happy to be corrected

void_volumelab19:05

is SURMOUNT-OSA the sleep apnoea one

meniscus_mel 19:16

£72 for a 15 vial is roughly what ive paid for the last year

void_volumelab19:20

went back to semaglutide after 3 months because the cost difference mattered more than the GI

switched last year

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

void_volumelab19:37

for the archive 5 was where i first noticed it properly, 2.5 did almost nothing for me

meniscus_mel £72 for a 15 vial is roughly what ive paid for the last year

void_volumelab19:50

unrelated but the sweet spot argument is really about effect per side effect, not a magic number

i went to 15 and came back to 10, more suppression wasnt more useful for me

thirty_min_wait 19:56

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

📈5🤝8👀7

thirty_min_wait 20:10

i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from

	Trial schedule	What most people here do
Step interval	4 weeks, fixed	4-12 weeks, on symptoms
Holding	protocol deviation	normal and expected
Top dose	reached by design	often never reached
Coming down	not studied	common at maintenance

quick one dual agonist, GIP as well as GLP-1, thats the whole difference in one line

lean_mass_lex i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more

thirty_min_wait 20:16

restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists

🧪14

meniscus_mel 20:18

how long before the dual thing was noticeable to you

[edited]

void_volume switched last year

seven_five_sweet 20:21

is there a reason to titrate slower than the four week schedule

lean_mass_lex 20:31

no clean conversion

🤝4

seven_five_sweet 20:45

at 12 my appetite is gone entirely, did anyone go down rather than up

sharps_bin_sid 20:47

whats the plateau pattern here, same as semaglutide or different

[edited]

sharps_bin_sid 20:58

the two compounds arent interchangeable week for week even if the effect ends up similar, still working it out
the sweet spot thing is survivorship, the people it worked for stayed and said so

ring_size_down 21:00

does the appetite effect feel different or just stronger

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

📈7

ring_size_down 21:25

changed my mind about needing 15, i was chasing a number rather than an outcome

seven_five_sweet 21:27

if youre coming off semaglutide the honest answer is start low and find out, theres no table

	Trial schedule	What most people here do
Step interval	4 weeks, fixed	4-12 weeks, on symptoms
Holding	protocol deviation	normal and expected
Top dose	reached by design	often never reached
Coming down	not studied	common at maintenance

void_volume switched last year

seven_five_sweet 21:40

the 2.5 to 5 step was the roughest one for me and everything after was easier

titrate slow

seven_five_sweet 21:47

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

ring_size_down does the appetite effect feel different or just stronger

seven_five_sweet 21:48

is the sweet spot argument about effect or about side effects

thirty_min_wait 21:50

plateaued at 10 weeks the same way i did on semaglutide, so i doubt its compound specific