the appetite effect faded for me around 20 months and going up fixed it for a while
#semaglutide 2026-06-22
Monday40 messages8 participantstimes are UTC
Highlights from this day
- warsaw_vial — the long half life flattens the trough more than people expect, i never felt a day seven dip 19:54
- dana_titrates — genuine question if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 20:13
- dana_titrates — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 20:14
- warsaw_vial — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 20:19
held at 1.7 and lost 54lb over 24 months, slower than the trials and fine by me, still working it out
my 40 vial in 1.5ml gives 5mg/ml so 2.5 lands on 15 units, thats why i picked that volume
dose day is sunday for me only because thats when i remember, not because sunday matters
*mg/ml, obviously
while im here i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
vials not pens here
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does the seven day half life mean the last two days are weaker
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SELECT wasnt weight
seven days ish
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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did anyone hold at 2.5 longer than four weeks before going up
restarted after 23 months off at a low dose and the nausea arrived exactly like the first time
was SELECT the one that ran to 68 weeks or am i mixing them up
£94 a month for compounded against what brand costs locally is why most people here use vials
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
brand vs compounded, is there a difference people can actually feel
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
Purity check: no report on file for lot SG-1177. Nothing logged either way.
how did people handle the jump from 1 to 1.7
went too fast once
24 months at 2.4 and the honest summary is diminishing returns after the first half, ill dig out the number
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the long half life flattens the trough more than people expect, i never felt a day seven dip
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Archive lookup: mag_citrate first appears in this channel on 2026-05-06.
genuine question if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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compounded and brand felt the same to me at 1.7, which is one person and nothing more
vial units and pen clicks are different systems, mixing the two is how people end up wrong
i held at 0.25 for 8 months and it was the best decision i made
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
five week steps worked better for me than four, purely on how the second week felt
same dose day
back after 25 months off, do i restart at 0.25 or somewhere higher
steady state takes weeks
does the licensed ceiling for weight differ from the diabetes one
[edited]moving my dose day by a day or two never did anything noticeable for me
half life is about a week so youre roughly four to five weeks to steady state on any new dose
held there too
not the same trial
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
the plateau hit me at 14 weeks and moved again about a month later without a dose change, ymmv