On this day 3 years ago this channel logged 26 messages.
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#semaglutide 2026-06-21
Sunday19 messages6 participantstimes are UTC
Highlights from this day
- VialBot — On this day 3 years ago this channel logged 26 messages. 16:40
- otto_swirls — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 17:29
- split_dose_sam — dose day is sunday for me only because thats when i remember, not because sunday matters 18:06
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i dont think the plateau is a dose problem most of the time, but i cant prove that
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
is the plateau at 30 weeks normal or am i doing something wrong
back after 8 months off, do i restart at 0.25 or somewhere higher
restarted after 13 months off at a low dose and the nausea arrived exactly like the first time
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgquick one STEP 1 ran to 68 weeks. thats the one everyone half remembers, from memory
give it four weeks
dose day is sunday for me only because thats when i remember, not because sunday matters
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slower worked better
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
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is the plateau usually appetite coming back or just the scale stopping
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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held there too
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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is there a reason to hold at 1.7 rather than going to 2.4
the long half life flattens the trough more than people expect, i never felt a day seven dip, for what its worth