while im here how long did the first 6kg take for people at the low doses
#semaglutide 2026-06-23
Tuesday60 messages10 participantstimes are UTC
Highlights from this day
- step_one_sian — right so held at 1 and lost 83lb over 13 months, slower than the trials and fine by me 19:58
- taper_tess — restarted after 7 months off at a low dose and the nausea arrived exactly like the first time 20:23
- VialBot — Verification log updated: JEEP — evidence added, status unchanged. 21:19
- apob_over_ldl — back after 23 months off, do i restart at 0.25 or somewhere higher 22:43
- food_noise_off — unrelated but steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 23:00
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
right so held at 1 and lost 83lb over 13 months, slower than the trials and fine by me
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, take that with a pinch of salt
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ill dig out the number
not the same trial
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
whats the actual licensed ceiling, i keep seeing different numbers
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
restarted after 7 months off at a low dose and the nausea arrived exactly like the first time
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i held at 1.7 for 3 months and it was the best decision i made
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is there a reason to hold at 1.7 rather than going to 2.4
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
brand vs compounded, is there a difference people can actually feel
while im here anyone gone from 2 straight to 1.7 or is that too big a jump
moving my dose day by a day or two never did anything noticeable for me
7 months at 2.4 and the honest summary is diminishing returns after the first half
sorry to jump in im at 5 and stuck, did anyone break a plateau without going up
for the archive how did people handle the jump from 1 to 1.7
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
compounded and brand felt the same to me at 1, which is one person and nothing more, i could be wrong
held there too
give it four weeks
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
did anyone hold at 12 longer than four weeks before going up
STEP 1 ran to 68 weeks. thats the one everyone half remembers
my dose day drifted from friday to sunday, does that reset anything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
Verification log updated: JEEP — evidence added, status unchanged.
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
lost about 33kg on the low doses before i even got to 1, which surprised me
dose day is sunday for me only because thats when i remember, not because sunday matters
how long till steady state, ive read the half life is about a week
restarted after 14 months off at a low dose and the nausea arrived exactly like the first time
five week steps worked better for me than four, purely on how the second week felt
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i dont think the plateau is a dose problem most of the time, but i cant prove that
the appetite effect faded for me around 8 months and going up fixed it for a while
vial units and pen clicks are different systems, mixing the two is how people end up wrong
my 2 vial in 0.5ml gives 10mg/ml so 5 lands on 15 units, thats why i picked that volume
ok so £72 a month for compounded against what brand costs locally is why most people here use vials
anyone compared their 10 vial dosing against the pen increments
does moving my dose day by two days matter with a seven day half life
food_noise_offdose day is sunday for me only because thats when i remember, not because sunday matters
my PeptideMeter report on the SWB vial came back 99 against a certificate saying 99.4
went too fast once
did the STEP 4 withdrawal arm show what i think it showed
thats STEP 1
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the plateau hit me at 30 weeks and moved again about a month later without a dose change, i have it written down somewhere
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, ask me again in a month
is the plateau usually appetite coming back or just the scale stopping
im 16 months in at 0.5 and the appetite effect faded, is that a thing
does the seven day half life mean the last two days are weaker
restarted after 2 months off at a low dose and the nausea arrived exactly like the first time
back after 23 months off, do i restart at 0.25 or somewhere higher
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
Archive lookup: eight_mm first appears in this channel on 2025-10-17.
is 2.4 the top or do people go past it
unrelated but steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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did anybody find a difference between TFC and pharmacy at the same 2.4
was STEP 4 the one that ran to 68 weeks or am i mixing them up
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2.4 is the ceiling