the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
peptidemeter-summary-e-2205.pdf
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#semaglutide 2026-05-13
Wednesday41 messages8 participantstimes are UTC
Highlights from this day
- month_six_me — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 22:02
- evidence_or_not — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 23:19
- evidence_or_not — does the licensed ceiling for weight differ from the diabetes one 23:38
the long half life flattens the trough more than people expect, i never felt a day seven dip
vial units and pen clicks are different systems, mixing the two is how people end up wrong, i have it written down somewhere
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
what did SELECT actually measure, i see it quoted for everything
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
[edited]SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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mine faded too
i dont think the plateau is a dose problem most of the time, but i cant prove that
not the same trial
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
same dose day
is 2.4 the top or do people go past it
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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New independent result logged — GL Biochem, lot A-2601, purity 99% (PeptideMeter).
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, i think
[edited]STEP is several trials, so saying STEP said x is usually wrong without a number after it
my 20 vial in 2.5ml gives 10mg/ml so 1.7 lands on 25 units, thats why i picked that volume
how long did the first 45kg take for people at the low doses
2.4 is the ceiling
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
lost about 39kg on the low doses before i even got to 1, which surprised me
SELECT wasnt weight
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my dose day drifted from friday to sunday, does that reset anything
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
thats STEP 1
five week steps worked better for me than four, purely on how the second week felt
anyone compared their 8 vial dosing against the pen increments
i held at 2.4 for 8 months and it was the best decision i made
give it four weeks
how did people handle the jump from 1 to 1.7
vials not pens here
does moving my dose day by two days matter with a seven day half life
im 25 months in at 10 and the appetite effect faded, is that a thing
did anyone titrate slower than four weeks a step and how did that go
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was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
is the plateau at 2 weeks normal or am i doing something wrong
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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does the licensed ceiling for weight differ from the diabetes one
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update on the earlier thing if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule