#semaglutide 2026-05-14

vials not pens here

held at 1 and lost 77lb over 10 months, slower than the trials and fine by me, still working it out

unrelated but STEP is several trials, so saying STEP said x is usually wrong without a number after it

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

2.4 is the ceiling

how long till steady state, ive read the half life is about a week

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

i stayed on 1.7 for 1 months and never went to 2.4, appetite was already where i needed it

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

my Janoshik report on the JEEP vial came back 96.8 against a certificate saying 97.4, happy to be corrected

the appetite effect faded for me around 14 months and going up fixed it for a while

does the seven day half life mean the last two days are weaker

held there too

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

the plateau hit me at 19 weeks and moved again about a month later without a dose change

steady state takes weeks

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

half life is about a week so youre roughly four to five weeks to steady state on any new dose, thats one data point

thats STEP 1

not the same trial

is there a reason to hold at 1.7 rather than going to 2.4

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

Verification log updated: SGN — evidence added, status unchanged.

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

plateaus move

mine faded too

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ask me again in a month

slower worked better

i held at 0.5 for 3 months and it was the best decision i made

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

did anyone hold at 0.25 longer than four weeks before going up

£240 a month for compounded against what brand costs locally is why most people here use vials

seven days ish

22 months at 2.4 and the honest summary is diminishing returns after the first half
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

held there too

anyone gone from 0.5 straight to 2 or is that too big a jump

genuine question anyone compared their 5 vial dosing against the pen increments

Verification log updated: CPC — evidence added, status unchanged.

give it four weeks

what did SELECT actually measure, i see it quoted for everything

the long half life flattens the trough more than people expect, i never felt a day seven dip

lost about 45kg on the low doses before i even got to 1, which surprised me