five week steps worked better for me than four, purely on how the second week felt
#semaglutide 2026-05-12
Tuesday73 messages13 participantstimes are UTC
Highlights from this day
- eight_mm — what did SELECT actually measure, i see it quoted for everything 15:58
- surpass_two — coming back to this my Janoshik report on the FGP vial came back 99 against a certificate saying 98.1, from memory 17:38
- dana_titrates — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 17:50
- dana_titrates — did anybody find a difference between QYB and pharmacy at the same 7.5 18:13
- freeze_thaw — update on the earlier thing slower worked better 20:03
is 2.4 the top or do people go past it
back after 5 months off, do i restart at 0.25 or somewhere higher
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
quick one i dont think the plateau is a dose problem most of the time, but i cant prove that
how many weeks before you noticed anything at 5
[edited]$185 a month for compounded against what brand costs locally is why most people here use vials, take that with a pinch of salt
did anyone titrate slower than four weeks a step and how did that go
mine faded too
genuine question went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
half life is about a week so youre roughly four to five weeks to steady state on any new dose
seven days ish
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held there too
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
anyone gone from 2 straight to 2.5 or is that too big a jump
[edited]does the licensed ceiling for weight differ from the diabetes one
im at 2.4 and stuck, did anyone break a plateau without going up
does the seven day half life mean the last two days are weaker
my dose day drifted from friday to sunday, does that reset anything
went too fast once
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moving my dose day by a day or two never did anything noticeable for me
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is there a reason to hold at 1.7 rather than going to 2.4
what did SELECT actually measure, i see it quoted for everything
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genuine question i held at 2.5 for 3 months and it was the best decision i made
i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i think
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, thats one data point
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
does anyone actually run a five week step instead of four
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steady state takes weeks
*week 24 not week 2
SELECT wasnt weight
same dose day
brand vs compounded, is there a difference people can actually feel
update on the earlier thing how long till steady state, ive read the half life is about a week
ok so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
ok so STEP 1 ran to 68 weeks. thats the one everyone half remembers
while im here restarted after 13 months off at a low dose and the nausea arrived exactly like the first time
is the plateau usually appetite coming back or just the scale stopping
vial units and pen clicks are different systems, mixing the two is how people end up wrong, from memory
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, anyway
vials not pens here
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
coming back to this my Janoshik report on the FGP vial came back 99 against a certificate saying 98.1, from memory
lost about 8kg on the low doses before i even got to 1, which surprised me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
2.4 is the ceiling
give it four weeks
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
does moving my dose day by two days matter with a seven day half life
slower worked better
did anybody find a difference between QYB and pharmacy at the same 7.5
18 months at 2.4 and the honest summary is diminishing returns after the first half
is the plateau at 15 weeks normal or am i doing something wrong
my 20 vial in 3ml gives 2.5mg/ml so 1 lands on 12 units, thats why i picked that volume
held at 1.7 and lost 36lb over 9 months, slower than the trials and fine by me
how long did the first 9kg take for people at the low doses
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
seven days ish
the plateau hit me at 6 weeks and moved again about a month later without a dose change
dose day is sunday for me only because thats when i remember, not because sunday matters, your mileage will differ
dose day is sunday for me only because thats when i remember, not because sunday matters
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the appetite effect faded for me around 23 months and going up fixed it for a while
update on the earlier thing slower worked better
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
did the STEP 4 withdrawal arm show what i think it showed
thats STEP 1
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
did anyone hold at 15 longer than four weeks before going up