five week steps worked better for me than four, purely on how the second week felt
20 months at 2.4 and the honest summary is diminishing returns after the first half
#semaglutide 2026-01-24
Saturday65 messages12 participantstimes are UTC
Highlights from this day
- brisbane_bac — coming back to this vial units and pen clicks are different systems, mixing the two is how people end up wrong, anyway 21:59
- birch_bloods — how long till steady state, ive read the half life is about a week 22:03
- no_escrow_nate — is 2.4 the top or do people go past it 23:14
- surpass_two — slightly off topic but thats STEP 1 23:24
is there a reason to hold at 1.7 rather than going to 2.4
dose day is sunday for me only because thats when i remember, not because sunday matters, thats one data point
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right so is the plateau usually appetite coming back or just the scale stopping
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restarted after 23 months off at a low dose and the nausea arrived exactly like the first time
plateaus move
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, happy to be corrected
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held there too
does the seven day half life mean the last two days are weaker
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
brand vs compounded, is there a difference people can actually feel
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
moving my dose day by a day or two never did anything noticeable for me
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
my VendorInvestigate report on the ERP vial came back 98.1 against a certificate saying 98.6
quick one does anyone actually run a five week step instead of four
did anyone hold at 7.5 longer than four weeks before going up
STEP is several trials, so saying STEP said x is usually wrong without a number after it
same dose day
slightly off topic but 8 months at 2.4 and the honest summary is diminishing returns after the first half
SELECT wasnt weight
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im at 1 and stuck, did anyone break a plateau without going up
slower worked better
thats STEP 1
seven days ish
the appetite effect faded for me around 11 months and going up fixed it for a while, ask me again in a month
amsterdam_aliquotrestarted after 23 months off at a low dose and the nausea arrived exactly like the…
coming back to this how long did the first 47kg take for people at the low doses
how many weeks before you noticed anything at 15
Recon calculator: 2mg in 3ml = 2mg/ml.
mine faded too
2.4 is the ceiling
went too fast once
is the plateau at 17 weeks normal or am i doing something wrong
steady state takes weeks
give it four weeks
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
sorry to jump in STEP 1 ran to 68 weeks. thats the one everyone half remembers
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$94 a month for compounded against what brand costs locally is why most people here use vials
held at 2.4 and lost 25lb over 14 months, slower than the trials and fine by me
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coming back to this vial units and pen clicks are different systems, mixing the two is how people end up wrong, anyway
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how long till steady state, ive read the half life is about a week
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the plateau hit me at 17 weeks and moved again about a month later without a dose change
unrelated but anyone compared their 2.5 vial dosing against the pen increments
what did SELECT actually measure, i see it quoted for everything
sorry to jump in did anybody find a difference between WXT and pharmacy at the same 2.5
fridge-temps.csv
585 rows · not retained in the public archive
i held at 5 for 2 months and it was the best decision i made
how did people handle the jump from 1 to 1.7
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*VendorInvestigate not the other one
ok so anyone gone from 15 straight to 1 or is that too big a jump
not the same trial
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Testing queue: 3 submissions open, 113 awaiting dispatch.
right so was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
did anyone titrate slower than four weeks a step and how did that go
[edited]does moving my dose day by two days matter with a seven day half life
did the STEP 4 withdrawal arm show what i think it showed
compounded and brand felt the same to me at 12, which is one person and nothing more
i dont think the plateau is a dose problem most of the time, but i cant prove that
whats the actual licensed ceiling, i keep seeing different numbers
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
is 2.4 the top or do people go past it
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ymmv
slightly off topic but thats STEP 1
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