lost about 14kg on the low doses before i even got to 1, which surprised me
#semaglutide 2026-01-25
Sunday27 messages8 participantstimes are UTC
Highlights from this day
- VialBot — Reminder for igf_one_ivy: dose day is today. Set 5 days ago. 20:40
- vale_vials — slightly off topic but was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up 21:37
- thirty_one_g — dose day is sunday for me only because thats when i remember, not because sunday matters 21:52
- mira_pins — did anyone titrate slower than four weeks a step and how did that go 22:47
- thirty_one_g — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 22:55
anyone compared their 2 vial dosing against the pen increments
quick one the appetite effect faded for me around 1 months and going up fixed it for a while, i could be wrong
vials not pens here
im at 0.5 and stuck, did anyone break a plateau without going up
Reminder for igf_one_ivy: dose day is today. Set 5 days ago.
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, from memory
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
anyone gone from 5 straight to 10 or is that too big a jump
is there a reason to hold at 1.7 rather than going to 2.4
back after 15 months off, do i restart at 0.25 or somewhere higher
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
moving my dose day by a day or two never did anything noticeable for me, still working it out
€120 a month for compounded against what brand costs locally is why most people here use vials
not the same trial
slightly off topic but was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
👍11
held there too
2.4 is the ceiling
dose day is sunday for me only because thats when i remember, not because sunday matters
✅4
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ask me again in a month
thats STEP 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, ask me again in a month
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
did anyone titrate slower than four weeks a step and how did that go
🙏6
slower worked better
the plateau hit me at 32 weeks and moved again about a month later without a dose change
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
📈13😂8
what did SELECT actually measure, i see it quoted for everything