moving my dose day by a day or two never did anything noticeable for me
#semaglutide 2026-01-23
Friday24 messages6 participantstimes are UTC
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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mine faded too
same dose day
does moving my dose day by two days matter with a seven day half life
how did people handle the jump from 1 to 1.7
the long half life flattens the trough more than people expect, i never felt a day seven dip
lost about 39kg on the low doses before i even got to 1, which surprised me
while im here SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
not the same trial
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg⚠️1
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, ask me again in a month
5 months at 2.4 and the honest summary is diminishing returns after the first half
how many weeks before you noticed anything at 2
Batch lookup E-2205: 6 independent reports on file, earliest 2025-11-19.
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does the licensed ceiling for weight differ from the diabetes one
my 15 vial in 3ml gives 10mg/ml so 5 lands on 10 units, thats why i picked that volume
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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held there too
ok so FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the plateau hit me at 28 weeks and moved again about a month later without a dose change, anyway
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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did the STEP 4 withdrawal arm show what i think it showed
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€240 a month for compounded against what brand costs locally is why most people here use vials