#semaglutide 2026-01-15

was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up

dose day is sunday for me only because thats when i remember, not because sunday matters

STEP is several trials, so saying STEP said x is usually wrong without a number after it

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

vial units and pen clicks are different systems, mixing the two is how people end up wrong

did anybody find a difference between HJ and pharmacy at the same 1.7

thats STEP 1

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

does the licensed ceiling for weight differ from the diabetes one

seven days ish

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

the appetite effect faded for me around 22 months and going up fixed it for a while

im 12 months in at 0.5 and the appetite effect faded, is that a thing

STEP 1 ran to 68 weeks. thats the one everyone half remembers, ask me again in a month

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, ymmv

does moving my dose day by two days matter with a seven day half life

went too fast once

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

for the archive half life is about a week so youre roughly four to five weeks to steady state on any new dose
restarted after 1 months off at a low dose and the nausea arrived exactly like the first time

plateaus move

genuine question lost about 7kg on the low doses before i even got to 1, which surprised me, ymmv

slower worked better

changed my mind on the four week rule, i think it depends entirely on how the current dose feels, your mileage will differ

the long half life flattens the trough more than people expect, i never felt a day seven dip

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

Archive lookup: surpass_two first appears in this channel on 2025-04-27.

quick one anyone gone from 5 straight to 0.5 or is that too big a jump

did the STEP 4 withdrawal arm show what i think it showed

right so moving my dose day by a day or two never did anything noticeable for me

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, i have it written down somewhere

is there a reason to hold at 1.7 rather than going to 2.4

same dose day

i held at 2.4 for 3 months and it was the best decision i made

*Janoshik not the other one

whats the actual licensed ceiling, i keep seeing different numbers

is the plateau at 24 weeks normal or am i doing something wrong

i dont think the plateau is a dose problem most of the time, but i cant prove that

i stayed on 1.7 for 12 months and never went to 2.4, appetite was already where i needed it

SELECT wasnt weight