steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
#semaglutide 2026-01-16
Friday35 messages8 participantstimes are UTC
Highlights from this day
- taper_tess — this. week 68 results are not week 12 results 08:13
- taper_tess — roughly, and these are means from different trials so dont read the last column as a race 09:22
- VialBot — archive lookup: `STEP 1` appears in 214 logged lines across #semaglutide, #dosing-titration and #wins. earliest 2023-10-02. 10:15
is there a reason to hold at 1.7 rather than going to 2.4
dose day is sunday for me only because thats when i remember, not because sunday matters
SELECT wasnt weight
janoshik-b-0114.pdf
2 pages · 627 KB · not retained in the public archive
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
does the seven day half life mean the last two days are weaker
someone quoted STEP 1 at me like it ends the conversation. does it
it ends the conversation about what the drug did in that trial. nothing else
68 weeks at 2.4mg weekly, mean weight change about -14.9% vs about -2.4% on placebo
so 15%
so 15% on average. the average is not a promise
the spread is the bit nobody quotes. plenty of people well past 20 and plenty barely moved
i was one of the barely moved ones for the first 4 months and then it went
how long is 4 months on 2.4
no i wasnt on 2.4 at 4 months, i was still climbing. thats sort of my point
the trial titrates over 16 weeks. people forget the first four months of the trial are also titration
this. week 68 results are not week 12 results
✅6
ok whats STEP 8 then, someone else sent me that one
sema 2.4 came in around -15.8% and lira 3.0 around -6.4%
which is why almost nobody in here talks about liraglutide anymore
the daily injection was the killer for me honestly, not the mcg
*not the numbers. autocorrect
can i see them side by side
roughly, and these are means from different trials so dont read the last column as a race
| Trial | Drug / dose | Weeks | Mean weight change |
|---|---|---|---|
| STEP 1 (NEJM 2021) | semaglutide 2.4 mg | 68 | about -15% |
| STEP 3 (JAMA 2021) | sema 2.4 + intensive behavioural | 68 | about -16% |
| STEP 8 (JAMA 2022) | semaglutide 2.4 mg | 68 | about -16% |
| STEP 8 (JAMA 2022) | liraglutide 3.0 mg | 68 | about -6% |
STEP 3 barely beat STEP 1 and that had a whole diet programme bolted on
yep. thats the uncomfortable finding and people skip past it
different populations, different sites, you cannot subtract one trial from another
agreed, i said dont read it as a race
worth saying out loud since @first_vial_finn is new — none of us are telling you what to take. this is just what got published and what happened to us
understood, im just trying to get my head round the baseline before i decide anything
👍3
archive lookup: STEP 1 appears in 214 logged lines across #semaglutide, #dosing-titration and #wins. earliest 2023-10-02.
214 and probably 200 of them are someone explaining that a mean is a mean
the channel in one number
😂9💀3