genuine question going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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#semaglutide 2025-12-02
Tuesday49 messages10 participantstimes are UTC
Highlights from this day
- mg_per_ml — genuine question going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 11:37
- bac_water_bill — is there a reason to hold at 1.7 rather than going to 2.4 if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 11:43
- bac_water_bill — held at 7.5 and lost 26lb over 19 months, slower than the trials and fine by me if youre comparing brand to compounded, dose accuracy in the vial is the variable, not… 13:20
- bea_reconstitutes — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, from memory 14:45
- bac_water_bill — my 2 vial in 1.5ml gives 4mg/ml so 15 lands on 12 units, thats why i picked that volume half life is about a week so youre roughly four to five weeks to steady state… 15:04
mine faded too
is there a reason to hold at 1.7 rather than going to 2.4
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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same dose day
lost about 43kg on the low doses before i even got to 1, which surprised me, still working it out
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
i dont think the plateau is a dose problem most of the time, but i cant prove that
2.4 is the ceiling
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slower worked better
my Janoshik report on the Homopeptide vial came back 99.2 against a certificate saying 98.6
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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brand vs compounded, is there a difference people can actually feel
coming back to this did anyone hold at 12 longer than four weeks before going up
vial units and pen clicks are different systems, mixing the two is how people end up wrong, we shall see
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i held at 0.5 for 8 months and it was the best decision i made
STEP 1 ran to 68 weeks. thats the one everyone half remembers, still working it out
held at 7.5 and lost 26lb over 19 months, slower than the trials and fine by me
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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does the seven day half life mean the last two days are weaker
steady state takes weeks
seven days ish
did anybody find a difference between SWB and pharmacy at the same 12
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
is the plateau usually appetite coming back or just the scale stopping
€185 a month for compounded against what brand costs locally is why most people here use vials
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went too fast once
SELECT wasnt weight
coming back to this restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
compounded and brand felt the same to me at 2.4, which is one person and nothing more
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, from memory
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thats STEP 1
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anyone gone from 2 straight to 1 or is that too big a jump
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16 months at 2.4 and the honest summary is diminishing returns after the first half, your mileage will differ
my 2 vial in 1.5ml gives 4mg/ml so 15 lands on 12 units, thats why i picked that volume
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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genuine question i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it
plateaus move
give it four weeks
moving my dose day by a day or two never did anything noticeable for me
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
compounded and brand felt the same to me at 7.5, which is one person and nothing more
update on the earlier thing STEP is several trials, so saying STEP said x is usually wrong without a number after it
how many weeks before you noticed anything at 2.4
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, i have it written down somewhere
the long half life flattens the trough more than people expect, i never felt a day seven dip
not the same trial
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
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steady state takes weeks