the long half life flattens the trough more than people expect, i never felt a day seven dip
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#semaglutide 2025-12-01
Monday28 messages6 participantstimes are UTC
Highlights from this day
- sage_sources — the long half life flattens the trough more than people expect, i never felt a day seven dip 14:53
- sage_sources — moving my dose day by a day or two never did anything noticeable for me 14:57
- thirty_one_g — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 15:12
- sage_sources — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 16:42
- noct.titrate — for the archive the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 17:24
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
2.4 is the ceiling
moving my dose day by a day or two never did anything noticeable for me
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
lost about 28kg on the low doses before i even got to 1, which surprised me
how did people handle the jump from 1 to 1.7
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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held there too
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the appetite effect faded for me around 22 months and going up fixed it for a while
held at 15 and lost 35lb over 25 months, slower than the trials and fine by me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
my VendorInvestigate report on the SGN vial came back 99.2 against a certificate saying 99.4, ymmv
whats the actual licensed ceiling, i keep seeing different numbers
i held at 15 for 3 months and it was the best decision i made
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
is the plateau usually appetite coming back or just the scale stopping
five week steps worked better for me than four, purely on how the second week felt, thats just me
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
SELECT wasnt weight
€185 a month for compounded against what brand costs locally is why most people here use vials
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
for the archive the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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did anyone hold at 2.5 longer than four weeks before going up
is the plateau at 18 weeks normal or am i doing something wrong
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
vials not pens here
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