if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
#semaglutide 2025-12-03
Wednesday43 messages8 participantstimes are UTC
Highlights from this day
- a1c_lag — slightly off topic but changed my mind on the four week rule, i think it depends entirely on how the current dose feels 18:31
- retention_time — slightly off topic but the plateau hit me at 3 weeks and moved again about a month later without a dose change 19:04
- stack_sceptic — unrelated but im at 0.25 and stuck, did anyone break a plateau without going up 21:05
how many weeks before you noticed anything at 15
five week steps worked better for me than four, purely on how the second week felt
how long till steady state, ive read the half life is about a week
slightly off topic but changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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thats STEP 1
dose day is sunday for me only because thats when i remember, not because sunday matters
18:50quiet.hours pinned a message to this channel
half life is about a week so youre roughly four to five weeks to steady state on any new dose
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
slower worked better
held at 1 and lost 10lb over 8 months, slower than the trials and fine by me
the long half life flattens the trough more than people expect, i never felt a day seven dip
mine faded too
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right so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, for what its worth
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slightly off topic but the plateau hit me at 3 weeks and moved again about a month later without a dose change
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
steady state takes weeks
STEP 1 ran to 68 weeks. thats the one everyone half remembers
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
im 26 months in at 2.4 and the appetite effect faded, is that a thing
what did SELECT actually measure, i see it quoted for everything
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
genuine question went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
brand vs compounded, is there a difference people can actually feel
went too fast once
moving my dose day by a day or two never did anything noticeable for me
my Janoshik report on the Homopeptide vial came back 98.6 against a certificate saying 99.4
quick one is the plateau usually appetite coming back or just the scale stopping
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not the same trial
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is the plateau at 23 weeks normal or am i doing something wrong
20 months at 2.4 and the honest summary is diminishing returns after the first half, ymmv
medutest-report-h-2814.pdf
3 pages · 621 KB · not retained in the public archive
unrelated but im at 0.25 and stuck, did anyone break a plateau without going up
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the appetite effect faded for me around 13 months and going up fixed it for a while
seven days ish
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, we shall see
anyone gone from 1.7 straight to 10 or is that too big a jump
same dose day
did anyone titrate slower than four weeks a step and how did that go
£120 a month for compounded against what brand costs locally is why most people here use vials
anyone compared their 4 vial dosing against the pen increments