i held at 1.7 for 2 months and it was the best decision i made
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#semaglutide 2025-11-02
Sunday36 messages10 participantstimes are UTC
Highlights from this day
- mg_per_ml — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 01:13
- apnoea_down_two — vial units and pen clicks are different systems, mixing the two is how people end up wrong 01:25
- nordic_price_nils — half life is about a week so youre roughly four to five weeks to steady state on any new dose 05:36
anyone gone from 5 straight to 7.5 or is that too big a jump
does moving my dose day by two days matter with a seven day half life
coming back to this went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, happy to be corrected
lost about 26kg on the low doses before i even got to 1, which surprised me
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compounded and brand felt the same to me at 2.4, which is one person and nothing more
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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2.4 is the ceiling
peptidemeter-summary-d-0718.pdf
2 pages · 557 KB · not retained in the public archive
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
how long did the first 4kg take for people at the low doses
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right so going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
while im here does the licensed ceiling for weight differ from the diabetes one
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my 10 vial in 1ml gives 4mg/ml so 1.7 lands on 10 units, thats why i picked that volume
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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five week steps worked better for me than four, purely on how the second week felt
went too fast once
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
how did people handle the jump from 1 to 1.7
the appetite effect faded for me around 10 months and going up fixed it for a while
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how long till steady state, ive read the half life is about a week
what did SELECT actually measure, i see it quoted for everything
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgmy Medutest report on the TFC vial came back 99 against a certificate saying 99.2
did anyone hold at 1 longer than four weeks before going up
held at 1.7 and lost 43lb over 19 months, slower than the trials and fine by me
the long half life flattens the trough more than people expect, i never felt a day seven dip
steady state takes weeks
back after 16 months off, do i restart at 0.25 or somewhere higher
sorry to jump in SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
plateaus move
half life is about a week so youre roughly four to five weeks to steady state on any new dose
coa-b-0114.pdf
1 page · 150 KB · not retained in the public archive
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did the STEP 4 withdrawal arm show what i think it showed
STEP 1 ran to 68 weeks. thats the one everyone half remembers
6 months at 2.4 and the honest summary is diminishing returns after the first half
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, your mileage will differ
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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