half life is about a week so youre roughly four to five weeks to steady state on any new dose, ask me again in a month
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#semaglutide 2025-11-05
Wednesday34 messages9 participantstimes are UTC
Highlights from this day
- back_from_away — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 20:26
- hydrate_hana — the plateau hit me at 22 weeks and moved again about a month later without a dose change, anyway i was wrong about the ceiling for a year, i thought 3 existed. it… 20:32
- egfr_ed — STEP is several trials, so saying STEP said x is usually wrong without a number after it 20:57
how long did the first 31kg take for people at the low doses
thats STEP 1
Inter-lab diff for lot SG-1177: 97.4% vs 98.1%. Within expected range.
dose day is sunday for me only because thats when i remember, not because sunday matters
medutest-report-c-4402.pdf
3 pages · 355 KB · not retained in the public archive
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give it four weeks
update on the earlier thing i held at 0.25 for 9 months and it was the best decision i made, thats just me
does moving my dose day by two days matter with a seven day half life
sorry to jump in 21 months at 2.4 and the honest summary is diminishing returns after the first half
Verification log updated: QYB — evidence added, status unchanged.
for the archive FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
not the same trial
does the licensed ceiling for weight differ from the diabetes one
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdoes anyone actually run a five week step instead of four
did anybody find a difference between WWB and pharmacy at the same 0.25
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the plateau hit me at 22 weeks and moved again about a month later without a dose change, anyway
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
restarted after 10 months off at a low dose and the nausea arrived exactly like the first time, happy to be corrected
STEP is several trials, so saying STEP said x is usually wrong without a number after it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgslower worked better
same dose day
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seven days ish
anyone compared their 4 vial dosing against the pen increments
SELECT wasnt weight
quick one was STEP 4 the one that ran to 68 weeks or am i mixing them up
held at 12 and lost 66lb over 5 months, slower than the trials and fine by me, i think
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, not advice obviously
vials not pens here
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i stayed on 1.7 for 25 months and never went to 2.4, appetite was already where i needed it, for what its worth
plateaus move
went too fast once
ok so the appetite effect faded for me around 13 months and going up fixed it for a while, anyway