vialroom

#semaglutide 2025-04-24

Thursday25 messages6 participantstimes are UTC
Highlights from this day
  • area_percent — the appetite effect faded for me around 18 months and going up fixed it for a while 18:06
  • cagri_curious — anyone gone from 2 straight to 1.7 or is that too big a jump 18:51
  • nausea_window — did anyone hold at 10 longer than four weeks before going up 18:56
AP

the appetite effect faded for me around 18 months and going up fixed it for a while

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AP

whats the actual licensed ceiling, i keep seeing different numbers

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

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how did people handle the jump from 1 to 1.7

CO

vial units and pen clicks are different systems, mixing the two is how people end up wrong, ymmv

AP

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

CC

anyone gone from 2 straight to 1.7 or is that too big a jump

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

my 20 vial in 2ml gives 10mg/ml so 1.7 lands on 12 units, thats why i picked that volume

RR

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

NW

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

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AP

im 22 months in at 15 and the appetite effect faded, is that a thing

AH

follow up going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, thats just me

2.4 is the ceiling

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

AP

restarted after 8 months off at a low dose and the nausea arrived exactly like the first time