STEP is several trials, so saying STEP said x is usually wrong without a number after it
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#semaglutide 2025-04-11
Friday51 messages8 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: GGPeps — evidence added, status unchanged. 16:56
- area_percent — im at 15 and stuck, did anyone break a plateau without going up 16:59
- spreadsheet_stu — back after 17 months off, do i restart at 0.25 or somewhere higher 18:32
- bea_reconstitutes — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 18:54
- VialBot — Assay note: SSA lot H-2814 reported at 99.2% of label content. 19:51
dose day is sunday for me only because thats when i remember, not because sunday matters
give it four weeks
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went too fast once
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i held at 0.25 for 5 months and it was the best decision i made
is the plateau usually appetite coming back or just the scale stopping
restarted after 7 months off at a low dose and the nausea arrived exactly like the first time
i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it
chain_of_custodywent to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
held at 2.4 and lost 39lb over 12 months, slower than the trials and fine by me
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for the archive SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did the STEP 4 withdrawal arm show what i think it showed
my PeptideMeter report on the SGN vial came back 97.4 against a certificate saying 99
lost about 37kg on the low doses before i even got to 1, which surprised me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
i dont think the plateau is a dose problem most of the time, but i cant prove that
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
the appetite effect faded for me around 20 months and going up fixed it for a while
Verification log updated: GGPeps — evidence added, status unchanged.
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how did people handle the jump from 1 to 1.7
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
compounded and brand felt the same to me at 1, which is one person and nothing more
im at 15 and stuck, did anyone break a plateau without going up
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thats STEP 1
not the same trial
plateaus move
while im here STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
did anyone titrate slower than four weeks a step and how did that go
the plateau hit me at 30 weeks and moved again about a month later without a dose change
same dose day
the long half life flattens the trough more than people expect, i never felt a day seven dip, we shall see
is 2.4 the top or do people go past it
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, happy to be corrected
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
back after 17 months off, do i restart at 0.25 or somewhere higher
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgTesting queue: 9 submissions open, 116 awaiting dispatch.
whats the actual licensed ceiling, i keep seeing different numbers
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgheld there too
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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2.4 is the ceiling
steady state takes weeks
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, thats one data point
quick one brand vs compounded, is there a difference people can actually feel
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
compounded and brand felt the same to me at 0.5, which is one person and nothing more
Assay note: SSA lot H-2814 reported at 99.2% of label content.
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five week steps worked better for me than four, purely on how the second week felt
vials not pens here
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the appetite effect faded for me around 24 months and going up fixed it for a while
[edited]was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
how long till steady state, ive read the half life is about a week
Archive lookup: area_percent first appears in this channel on 2024-09-08.