does the licensed ceiling for weight differ from the diabetes one
#semaglutide 2025-04-12
Saturday46 messages9 participantstimes are UTC
Highlights from this day
- abdo_two_inch — does the seven day half life mean the last two days are weaker 16:38
- lot_number_lou — was STEP 1 the one that ran to 68 weeks or am i mixing them up 19:11
- VialBot — On this day 4 years ago this channel logged 24 messages. 19:17
- nhs_pathway_nell — vial units and pen clicks are different systems, mixing the two is how people end up wrong 19:29
give it four weeks
does the seven day half life mean the last two days are weaker
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🧪6🔥5📉4
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
five week steps worked better for me than four, purely on how the second week felt
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lost about 16kg on the low doses before i even got to 1, which surprised me
while im here whats the actual licensed ceiling, i keep seeing different numbers
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
does anyone actually run a five week step instead of four
not the same trial
did anybody find a difference between SWB and pharmacy at the same 2
mine faded too
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anyone gone from 2 straight to 1 or is that too big a jump
vials not pens here
same dose day
right so £72 a month for compounded against what brand costs locally is why most people here use vials
steady state takes weeks
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how long did the first 37kg take for people at the low doses
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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what did SELECT actually measure, i see it quoted for everything
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, your mileage will differ
is 2.4 the top or do people go past it
compounded and brand felt the same to me at 1.7, which is one person and nothing more, thats just me
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
plateaus move
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
right so i held at 15 for 9 months and it was the best decision i made
the appetite effect faded for me around 18 months and going up fixed it for a while
back after 20 months off, do i restart at 0.25 or somewhere higher
went too fast once
thats STEP 1
quick one SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
right so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, i have it written down somewhere
was STEP 1 the one that ran to 68 weeks or am i mixing them up
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im 11 months in at 12 and the appetite effect faded, is that a thing
held at 1.7 and lost 49lb over 11 months, slower than the trials and fine by me
On this day 4 years ago this channel logged 24 messages.
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restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
the appetite effect faded for me around 8 months and going up fixed it for a while
10 months at 2.4 and the honest summary is diminishing returns after the first half
19:27marrow.mod pinned a message to this channel
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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the plateau hit me at 14 weeks and moved again about a month later without a dose change, ill dig out the number
step_one_siancompounded and brand felt the same to me at 1.7, which is one person and nothing more,…
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, your mileage will differ
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slower worked better