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#semaglutide 2025-03-26

Wednesday12 messages3 participantstimes are UTC
Highlights from this day
  • customs_owl — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 14:06
  • customs_owl — the appetite effect faded for me around 8 months and going up fixed it for a while 14:49
  • customs_owl — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, still working it out 16:07
  • ferritin_fay — update on the earlier thing went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 16:12
CO

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg
🤝1❤️12
CO

the appetite effect faded for me around 8 months and going up fixed it for a while

Cited study
Effects of Semaglutide on Chronic Kidney Disease in Type 2 Diabetes (FLOW)
New England Journal of Medicine · 2024
Renal outcomes. The one that changed a lot of nephrologists’ minds.

brand vs compounded, is there a difference people can actually feel

went too fast once

FF

i dont think the plateau is a dose problem most of the time, but i cant prove that

plateaus move

CO

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, still working it out

slower worked better

FF

update on the earlier thing went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down