vialroom

#semaglutide 2024-02-04

Sunday27 messages7 participantstimes are UTC
Highlights from this day
  • cold_chain_cmdr — im at 10 and stuck, did anyone break a plateau without going up 18:41
  • noct.titrate — the appetite effect faded for me around 13 months and going up fixed it for a while 19:11
  • cold_chain_cmdr — 6 months at 2.4 and the honest summary is diminishing returns after the first half 19:32
  • week_three_wall — anyone gone from 1 straight to 12 or is that too big a jump 20:06
  • quiet.hours — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 20:17
CC

sorry to jump in going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

CC

im at 10 and stuck, did anyone break a plateau without going up

Cited study
Effects of Semaglutide on Chronic Kidney Disease in Type 2 Diabetes (FLOW)
New England Journal of Medicine · 2024
Renal outcomes. The one that changed a lot of nephrologists’ minds.

SELECT wasnt weight

did the STEP 4 withdrawal arm show what i think it showed

i stayed on 1.7 for 15 months and never went to 2.4, appetite was already where i needed it

the appetite effect faded for me around 13 months and going up fixed it for a while

🧪9
WT

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

not the same trial

restarted after 10 months off at a low dose and the nausea arrived exactly like the first time, i think

CC

6 months at 2.4 and the honest summary is diminishing returns after the first half

📈4🧊15🙏4
CC

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

QH

does the licensed ceiling for weight differ from the diabetes one

did anybody find a difference between QSC and pharmacy at the same 10

QH

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

janoshik-b-0114.pdf
2 pages · 762 KB · not retained in the public archive

the long half life flattens the trough more than people expect, i never felt a day seven dip

WT

five week steps worked better for me than four, purely on how the second week felt

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, n of 1 obviously