anyone gone from 2 straight to 5 or is that too big a jump
#semaglutide 2024-01-27
Saturday36 messages9 participantstimes are UTC
Highlights from this day
- bea_reconstitutes — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 13:40
- deadspace — did anybody find a difference between CPC and pharmacy at the same 7.5 15:30
- taper_tess — held at 15 and lost 91lb over 2 months, slower than the trials and fine by me 15:33
- vialkeeper — i stayed on 1.7 for 26 months and never went to 2.4, appetite was already where i needed it 15:35
- retention_time — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 15:56
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
✅2👀10
what did SELECT actually measure, i see it quoted for everything
weights-monthly.csv
206 rows · not retained in the public archive
thats STEP 1
quick one the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
not the same trial
SELECT wasnt weight
seven days ish
slower worked better
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the plateau hit me at 32 weeks and moved again about a month later without a dose change
does the seven day half life mean the last two days are weaker
did the STEP 4 withdrawal arm show what i think it showed
⚠️7
ok so half life is about a week so youre roughly four to five weeks to steady state on any new dose
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
quick one is there a reason to hold at 1.7 rather than going to 2.4
whats the actual licensed ceiling, i keep seeing different numbers
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
[edited]went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
plateaus move
how long till steady state, ive read the half life is about a week
did anybody find a difference between CPC and pharmacy at the same 7.5
⚠️17📉11
sorry to jump in i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
held at 15 and lost 91lb over 2 months, slower than the trials and fine by me
😂14👍10
i stayed on 1.7 for 26 months and never went to 2.4, appetite was already where i needed it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg📈6✅17
mine faded too
[edited]2.4 is the ceiling
i dont think the plateau is a dose problem most of the time, but i cant prove that
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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im at 0.25 and stuck, did anyone break a plateau without going up
is the plateau usually appetite coming back or just the scale stopping
does moving my dose day by two days matter with a seven day half life
does anyone actually run a five week step instead of four
how long did the first 31kg take for people at the low doses
same dose day
held there too
steady state takes weeks
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial