not the same trial
#semaglutide 2024-02-05
Monday18 messages5 participantstimes are UTC
Highlights from this day
- mg_per_ml — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 18:39
- mg_per_ml — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 18:44
- slow.taper — compounded and brand felt the same to me at 2.5, which is one person and nothing more STEP 4 had the withdrawal arm, thats the one people quote when they talk about… 18:50
- bea_reconstitutes — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 20:34
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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im at 0.25 and stuck, did anyone break a plateau without going up
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgsteady state is the bit people skip, judging a new dose after eight days tells you almost nothing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
does moving my dose day by two days matter with a seven day half life
compounded and brand felt the same to me at 2.5, which is one person and nothing more
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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how long till steady state, ive read the half life is about a week
lost about 21kg on the low doses before i even got to 1, which surprised me
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does the licensed ceiling for weight differ from the diabetes one
does anyone actually run a five week step instead of four
my dose day drifted from friday to sunday, does that reset anything
how long did the first 44kg take for people at the low doses
my Janoshik report on the MKM vial came back 99 against a certificate saying 99.2
SELECT wasnt weight
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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