vialroom

#retatrutide 2025-05-24

Saturday47 messages12 participantstimes are UTC
Highlights from this day
  • triumph_watch — anyone tracking blood pressure alongside the heart rate 21:20
  • coa_or_cope — phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan 22:17
  • turnaround_tam — does the energy expenditure claim show up as anything you can feel 22:52
  • VialBot — Verification log updated: JEEP — evidence added, status unchanged. 23:10

the purity spread across lots worries me more than the molecule does

smaller steps here

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cant feel it honestly

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MM

while im here how slow is low and slow here, four weeks a step or longer

CC

the heart rate thing is real enough that i mention it whenever someone asks about starting

TW

genuine question triple agonist meaning GLP-1, GIP and glucagon, have i got that right

is the phase 2 dosing anywhere near what people here run

anyone tracking blood pressure alongside the heart rate

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CC

people insist on small steps because the side effects arrive faster than on the other two

sorry to jump in im at 10 and the appetite effect is stronger than i expected, normal

[edited]

anyone compared their Medutest purity across two different ERP lots

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

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FT

the honest position is this has less human evidence behind it than anything else discussed here

anyone reconstituting 30 vials to 4 so the steps come out smaller

no long term data

CC

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

[edited]

*PeptideMeter not the other one

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

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back after 4 months, has anything actually been published since

MM

for the archive lost 9kg over 22 months at doses well under what the trials used
my resting rate went up 4 bpm in the first month and came back most of the way by month 4

unrelated but did anyone come off because of the heart rate

appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point

RW

update on the earlier thing i log resting heart rate every morning because of this and its the one number i actually watch

CO

how do people square the research use only framing with logging their own use

does the glucagon arm explain the heart rate or is that unrelated

RW

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

stopped for 12 months and restarted at half my old dose, the ramp was easier second time

CO

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

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RW

my resting rate went up 4 bpm in the first month and came back most of the way by month 12

CO

my resting heart rate is up about 3 bpm, did that settle for anyone

[edited]
TT

does the energy expenditure claim show up as anything you can feel

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
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TT

quick one triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

VB

Verification log updated: JEEP — evidence added, status unchanged.

research use only

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