research use only
#retatrutide 2025-04-15
Tuesday45 messages11 participantstimes are UTC
Highlights from this day
- hydrate_hana — the heart rate thing is real enough that i mention it whenever someone asks about starting 15:36
- split_the_cost — sat at 1.7 for 2 months rather than climbing and it kept working, so i never went up, not advice obviously 17:49
- factory_direct_fi — anyone tracking blood pressure alongside the heart rate 18:51
- net_peptide — for the archive blood pressure stayed flat for me while heart rate moved, which i didnt expect 19:00
phase 2 only
right so my resting heart rate is up about 3 bpm, did that settle for anyone
reconstituted the 5 vial to 2mg/ml specifically so i could take 1.7 without measuring crumbs
triple agonist yeah
while im here nobody should read my log as a plan, im recording what i did and thats all it is
stepping in 5 increments instead of doubling is the only thing i would change if i started again
Janoshik came back 97.4 on one lot and 98.6 on the next from the same FGP, both fine
no idea whether the heart rate settles for everyone, mine did and one log isnt data
came off at 32 weeks because my resting rate stayed elevated and i didnt like it
mine went up too
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
people insist on small steps because the side effects arrive faster than on the other two, i could be wrong
the heart rate thing is real enough that i mention it whenever someone asks about starting
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watching my heart rate
does the energy expenditure claim show up as anything you can feel
i said 3 months ago that my heart rate had settled and it has stayed settled since
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
quick one phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
follow up the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
no long term data
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
held at 0.25 for 4 months and it never plateaued for me, which i cant explain
for the archive stopped for 10 months and restarted at half my old dose, the ramp was easier second time
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
glucagon is the new bit
right so i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
On this day 8 years ago this channel logged 51 messages.
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
the honest position is this has less human evidence behind it than anything else discussed here
low and slow
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
anyone compared their Medutest purity across two different KP lots
is TRIUMPH the phase 3 programme
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
sat at 1.7 for 2 months rather than climbing and it kept working, so i never went up, not advice obviously
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i log resting heart rate every morning because of this and its the one number i actually watch
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
lost 6kg over 20 months at doses well under what the trials used
anyone tracking blood pressure alongside the heart rate
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appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point, still working it out
how slow is low and slow here, four weeks a step or longer
sat at 5 for 3 months rather than climbing and it kept working, so i never went up
while im here back after 15 months, has anything actually been published since
for the archive blood pressure stayed flat for me while heart rate moved, which i didnt expect
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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settled by month three