vialroom

#retatrutide 2025-01-13

Monday20 messages6 participantstimes are UTC
Highlights from this day
  • ruo_only — extrapolation from the published trials to what people do here is the biggest weakness in the channel and it should be said out loud the published data is phase two,… 19:11
  • ruo_only — holding low, reporting there is no long term safety data. that is not a gap somebody will fill next month, it is the current state 19:22
  • VialBot — Verification log updated: QSC — 5 new documents attached. 19:24
  • freeze_thaw — nobody here is your clinician and this channel is the last place that should be treated as one, someone will correct me if you cannot point at the paper, say you… 20:09
RO

the purity spread across lots worries me more than the molecule does

RO

extrapolation from the published trials to what people do here is the biggest weakness in the channel and it should be said out loud
the published data is phase two, which is a very different evidence base from the licensed compounds

WZ

for the reta notes is there any long term safety data at all or is it phase 2 and hope

a year of notes later how do people think about titration when there is no approved ladder to copy, or should i ask this elsewhere — and anyone stopped because of something they saw in their own numbers

holding low, reporting is there any long term safety data at all or is that the honest gap, been going round in circles on it

RO

im at 7.5 and the appetite effect is stronger than i expected, normal

holding low, reporting there is no long term safety data. that is not a gap somebody will fill next month, it is the current state

👀5🧪84
VB

Verification log updated: QSC — 5 new documents attached.

👀15💀9
FT

do the reported effects differ from the dual agonist in a way anyone can describe — and has anyone here got an independent assay on this rather than a certificate

there is no label, so there is no ladder, and everything anybody does is somebody guess with a spreadsheet, phase two is all we have

say it out loud

what we actually know why does this channel talk in weeks rather than in steps, no rush — and is the glucagon arm what people mean by the energy expenditure thing

RO

this room does not tell anyone to take anything, and it especially does not here, not advice obviously

RO

being careful here the glucagon arm is the interesting part mechanistically and i cannot tell you i have felt it

is TRIUMPH the phase 3 programme, trying to get this right before i order

FT

nobody here is your clinician and this channel is the last place that should be treated as one, someone will correct me
if you cannot point at the paper, say you cannot point at the paper. that is allowed and it is better

one for the sceptics anyone got a reference for the phase 2 numbers rather than a summary of a summary, anyone at all

TT

the phase 2 results are published and citable. the summaries of them circulating in chat are not

CC

what would people want to see before treating any of this as established, or have i misread it