low and slow
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#retatrutide 2025-01-14
Tuesday29 messages7 participantstimes are UTC
Highlights from this day
is the glucagon arm what people mean by the energy expenditure thing
came off at 14 weeks because my resting rate stayed elevated and i didnt like it
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
slightly off topic but held at 1.7 for 20 months and it never plateaued for me, which i cant explain
how long before people saw the first change at 0.25
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the purity spread across lots worries me more than the molecule does, still working it out
triple agonist yeah
the honest position is this has less human evidence behind it than anything else discussed here, someone check my working
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
logging rhr daily
no long term data
research use only
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
held at 12 for 8 months and it never plateaued for me, which i cant explain
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
is TRIUMPH the phase 3 programme
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
no idea whether the heart rate settles for everyone, mine did and one log isnt data
update on the earlier thing does the glucagon arm explain the heart rate or is that unrelated
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is there any long term safety data at all or is it phase 2 and hope
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
i said 3 months ago that my heart rate had settled and it has stayed settled since
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
the half life supports weekly dosing and thats what ive done from the start, i think
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sorry to jump in there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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no idea whether the heart rate settles for everyone, mine did and one log isnt data, n of 1 obviously
Inter-lab diff for lot E-2205: 99.4% vs 97.4%. Within expected range.
is the phase 2 dosing anywhere near what people here run