glucagon is the new bit
#retatrutide 2025-01-12
Sunday26 messages5 participantstimes are UTC
Highlights from this day
- deamidation — reconstituted the 10 vial to 5mg/ml specifically so i could take 10 without measuring crumbs, ill dig out the number 23:00
- pbs_pip — genuine question whats the half life like, is it weekly the same way 23:19
- salt_bridge — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, still working it out 23:30
- salt_bridge — right so blood pressure stayed flat for me while heart rate moved, which i didnt expect 23:33
reconstituted the 10 vial to 5mg/ml specifically so i could take 10 without measuring crumbs, ill dig out the number
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does the glucagon arm explain the heart rate or is that unrelated
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
nobody should read my log as a plan, im recording what i did and thats all it is
my resting heart rate is up about 8 bpm, did that settle for anyone
low and slow
did anyone come off because of the heart rate
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
slightly off topic but im at 1.7 and the appetite effect is stronger than i expected, normal
slightly off topic but back after 3 months, has anything actually been published since
genuine question whats the half life like, is it weekly the same way
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the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, anyway
i log resting heart rate every morning because of this and its the one number i actually watch
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, still working it out
🔥15📈14
right so blood pressure stayed flat for me while heart rate moved, which i didnt expect
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no long term data
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settled by month three
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🎉15
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
how slow is low and slow here, four weeks a step or longer
slightly off topic but how long before people saw the first change at 15
[edited]slightly off topic but lost 11kg over 21 months at doses well under what the trials used
the purity spread across lots worries me more than the molecule does
triple agonist yeah
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom