if i hold at 2 indefinitely am i losing anything
#dosing-titration 2026-06-18
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the trials escalated on a fixed schedule because a trial has to. you are not a trial, ymmv
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two weeks is nothing
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
whats the smallest step anyone has managed between doses
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
is week 23 too early to be thinking about the next step
is there a trial anywhere that studied twice weekly, or is it all anecdote
i went from 12 to 15 and honestly could not tell the difference in appetite
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thats noise
i have been at 2 for 23 months and honestly i have stopped wanting to move
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the ladder in the trials is a starting point, not a schedule you owe anyone
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i escalate on symptoms. if the current dose is still doing something i stay on it
nobody here can tell you what dose to be on and the ones who try get corrected
update on the earlier thing is there a point where going up stops buying you anything
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
do you escalate on the calendar or on how you feel
my titration ladder took 24 months to climb and i would do it slower again
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slightly off topic but how do you tell a plateau from just being at your set point
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has anyone gone up and then straight back down and been glad they tried
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whats your rule for when a side effect means hold rather than push
update from 1 months ago: held at the same dose the whole time and still losing slowly
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you do not have to escalate at all. that is a real option that gets forgotten
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)split dosing has no trial behind it. people here do it and report on it, thats all, happy to be corrected
the honest answer is that most of us are running protocols nobody has ever studied
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ok so the honest answer is that most of us are running protocols nobody has ever studied