vialroom

#dosing-titration 2026-06-17

Wednesday52 messages9 participantstimes are UTC
Highlights from this day
  • bengaluru_bac — whats a sensible maintenance dose after a year at treatment dose 22:08
  • blind_submit — you do not have to escalate at all. that is a real option that gets forgotten 22:20
  • bengaluru_bac — the trials escalated on a fixed schedule because a trial has to. you are not a trial 22:35
  • two_lifts_a_week — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 22:54
  • dark_for_ten_days — my dose day has drifted 4 days later over 2 months, does it matter if you are going up because the scale stalled for two weeks, wait. two weeks is noise 23:10
SD
split_dose_sam21:11

quick one came down from a treatment dose to maintenance over about three months and it was uneventful, n of 1 obviously

DO
dexa_or_bia21:14

whats your rule for when a side effect means hold rather than push

21:16tenpence pinned a message to this channel

update on the earlier thing stepping back down on purpose is a completely reasonable move and this channel should say so more often

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

came down, no regrets

*that should say weekly

whats the longest anyone has stayed on one dose

n of 1

DF
dark_for_ten_days21:37

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, your mileage will differ

hold

😂17✅10🧊5

if you are asking whether to go up, the fact you are asking usually means not yet

i would hold

🎉15😂1

*Medutest not the other one

holding is not failing. most people here who lasted two years held at least one dose for months

BB
bengaluru_bac22:08

whats a sensible maintenance dose after a year at treatment dose

U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml
MP
mg_per_ml22:12

the honest answer is that most of us are running protocols nobody has ever studied

you do not have to escalate at all. that is a real option that gets forgotten

[edited]
U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml
🎉5

my titration ladder took 24 months to climb and i would do it slower again

TO
taper_or_not22:24

i went from 1 to 0.25 and honestly could not tell the difference in appetite

how much does the last dose still matter 3 days later

🔥3🧪1
BB
bengaluru_bac22:48

i hold for two months minimum before i decide a dose has stopped doing anything, we shall see

TL
two_lifts_a_week22:54

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

👀8🧪10
DF
dark_for_ten_days23:10

my dose day has drifted 4 days later over 2 months, does it matter
if you are going up because the scale stalled for two weeks, wait. two weeks is noise

[edited]
U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml

update question: did anyone who held for 8 months regret it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

[edited]

has anyone gone up and then straight back down and been glad they tried

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