if i took it 4 days late do i shift the schedule or go back to the old day
#dosing-titration 2026-06-19
Friday44 messages9 participantstimes are UTC
Highlights from this day
- step_one_sian — plateau versus set point is not answerable in under six months of data 20:22
- step_one_sian — update from 21 months ago: held at the same dose the whole time and still losing slowly 20:23
- sedge_sources — i hold for two months minimum before i decide a dose has stopped doing anything 20:42
- two_four_ceiling — you do not have to escalate at all. that is a real option that gets forgotten, ill dig out the number 21:01
- truncation_tru — for the archive split dosing has no trial behind it. people here do it and report on it, thats all 21:36
holding is not failing. most people here who lasted two years held at least one dose for months
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
do you tell your prescriber you held or do you just hold
half life is a week
for the archive how do you tell a plateau from just being at your set point
update on the earlier thing has anyone gone up and then straight back down and been glad they tried
genuine question small steps are better than big ones and the only reason people take big ones is impatience
how much does the last dose still matter 2 days later
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
hold
fridge-temps.csv
781 rows · not retained in the public archive
two weeks is nothing
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right so is there a trial anywhere that studied twice weekly, or is it all anecdote
the trials escalated on a fixed schedule because a trial has to. you are not a trial
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, ill dig out the number
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
pick a day and stick to it
i drifted from sunday to wednesday over a year and only noticed when i checked the log, someone check my working
plateau versus set point is not answerable in under six months of data
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update from 21 months ago: held at the same dose the whole time and still losing slowly
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i went from 1 to 0.5 and honestly could not tell the difference in appetite
slightly off topic but the honest answer is that most of us are running protocols nobody has ever studied
if i hold at 0.5 indefinitely am i losing anything
if it "stopped working after four days" that is almost never pharmacokinetics, anyway
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end of week thing
i hold for two months minimum before i decide a dose has stopped doing anything
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if you are asking whether to go up, the fact you are asking usually means not yet
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
you do not have to escalate at all. that is a real option that gets forgotten, ill dig out the number
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the people who do best here are almost always the ones going slowest
how long did you hold at 1.7 before you moved up
appetite returning at the end of the week is extremely common and is not the dose failing
i would hold
for the archive split dosing has no trial behind it. people here do it and report on it, thats all
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whats a sensible maintenance dose after a year at treatment dose
held for months
[edited]what does the room think about jumping a rung to catch up
coming back to this a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
do you count from injection day or from when you actually felt it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
is week 19 too early to be thinking about the next step
the ladder in the trials is a starting point, not a schedule you owe anyone, for what its worth
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unrelated but thats noise
is there a point where going up stops buying you anything
[edited]