while im here the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, anyway
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#dosing-titration 2026-06-16
Tuesday25 messages6 participantstimes are UTC
Highlights from this day
- meniscus_mel — update from 15 months ago: held at the same dose the whole time and still losing slowly 18:45
- meniscus_mel — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 19:05
- ruo_only — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 19:20
- invoice_mismatch — appetite returning at the end of the week is extremely common and is not the dose failing 19:39
nobody here can tell you what dose to be on and the ones who try get corrected
update from 15 months ago: held at the same dose the whole time and still losing slowly
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hold
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thats normal
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
genuine question with a roughly seven day half-life you are near steady state after about five weeks at a dose, ymmv
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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came down, no regrets
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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if i took it 6 days late do i shift the schedule or go back to the old day
slightly off topic but what does the room think about jumping a rung to catch up
i escalate on symptoms. if the current dose is still doing something i stay on it, take that with a pinch of salt
[edited]is week 3 too early to be thinking about the next step
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
appetite returning at the end of the week is extremely common and is not the dose failing
[edited]weights-monthly.csv
568 rows · not retained in the public archive
no trial for that
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stepping back down on purpose is a completely reasonable move and this channel should say so more often, happy to be corrected
update on the earlier thing does a missed week reset anything or do you just carry on
pick a day and stick to it
i went from 1 to 7.5 and honestly could not tell the difference in appetite, anyway
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steady state is 5 weeks
how long did you hold at 1.7 before you moved up