came down from a treatment dose to maintenance over about three months and it was uneventful
#dosing-titration 2025-11-26
Wednesday53 messages9 participantstimes are UTC
Highlights from this day
- two_three_lifts — small steps are better than big ones and the only reason people take big ones is impatience 19:48
- taper_or_not — how much does the last dose still matter 5 days later 20:39
- two_three_lifts — with a roughly seven day half-life you are near steady state after about five weeks at a dose 20:42
- two_three_lifts — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 20:51
i escalate on symptoms. if the current dose is still doing something i stay on it
nobody here can tell you what dose to be on and the ones who try get corrected, from memory
split dosing has no trial behind it. people here do it and report on it, thats all
is it normal for appetite to come back at the end of the week
is there a trial anywhere that studied twice weekly, or is it all anecdote
for the archive anyone here split their weekly into two and would they do it again
the honest answer is that most of us are running protocols nobody has ever studied
if i took it 3 days late do i shift the schedule or go back to the old day
i went up too fast and im paying for it, do i drop back or ride it out
👍3🔥5🧊3
is there a point where going up stops buying you anything
❤️1🤝1📉6
unrelated but the people who do best here are almost always the ones going slowest
if you are asking whether to go up, the fact you are asking usually means not yet
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, n of 1 obviously
*week 13 not week 7
i would hold
the ladder in the trials is a starting point, not a schedule you owe anyone
[edited]half life is a week
unrelated but holding is not failing. most people here who lasted two years held at least one dose for months
whats the smallest step anyone has managed between doses
if it "stopped working after four days" that is almost never pharmacokinetics
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
appetite returning at the end of the week is extremely common and is not the dose failing
anyone tracked whether a smaller more frequent dose changed their side effects
you do not have to escalate at all. that is a real option that gets forgotten
*that should say weekly
thats noise
came down, no regrets
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i went from 0.25 to 2 and honestly could not tell the difference in appetite
small steps are better than big ones and the only reason people take big ones is impatience
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg😂1
pick a day and stick to it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
too early imo
no trial for that
Reminder for two_three_lifts: dose day is today. Set 6 days ago.
💀4👍1
go slower
update from 6 months ago: held at the same dose the whole time and still losing slowly
stepping back down on purpose is a completely reasonable move and this channel should say so more often, n of 1 obviously
how much does the last dose still matter 5 days later
👍16🤝11
steady state is 5 weeks
😂1✅1🧊10
with a roughly seven day half-life you are near steady state after about five weeks at a dose
🤝1✅16❤️1
20:50marrow.mod pinned a message
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
✅6⚠️9
if the current dose is still working, going up is spending headroom you might want later
👍13🙏1🧪1
thats anecdote
whats your rule for when a side effect means hold rather than push
[edited]ok so after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, someone check my working
i hold for two months minimum before i decide a dose has stopped doing anything
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
22:00marrow.mod pinned a message