thats anecdote
#dosing-titration 2025-11-27
Thursday30 messages9 participantstimes are UTC
Highlights from this day
- VialBot — Reminder set. I will post here in 8 days. 11:16
- step_one_sian — i have been at 5 for 15 months and honestly i have stopped wanting to move 11:47
- rezept_rolf — how much does the last dose still matter 6 days later 13:45
- question_queue — how do you decide between holding and stepping when both feel wrong 13:50
- vale_vials — i drifted from sunday to wednesday over a year and only noticed when i checked the log 14:08
Reminder set. I will post here in 8 days.
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update from 23 months ago: held at the same dose the whole time and still losing slowly
i have been at 5 for 15 months and honestly i have stopped wanting to move
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n of 1
go slower
right so whats the smallest step anyone has managed between doses
[edited]my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
how long did you hold at 2.4 before you moved up
too early imo
my titration ladder took 16 months to climb and i would do it slower again
if it "stopped working after four days" that is almost never pharmacokinetics
pick a day and stick to it
how much does the last dose still matter 6 days later
[edited]wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgstepping back down on purpose is a completely reasonable move and this channel should say so more often
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
how do you decide between holding and stepping when both feel wrong
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anyone here split their weekly into two and would they do it again
the people who do best here are almost always the ones going slowest
i drifted from sunday to wednesday over a year and only noticed when i checked the log
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
whats a sensible maintenance dose after a year at treatment dose
the ladder in the trials is a starting point, not a schedule you owe anyone
appetite returning at the end of the week is extremely common and is not the dose failing
slightly off topic but i escalate on symptoms. if the current dose is still doing something i stay on it
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
you do not have to escalate at all. that is a real option that gets forgotten
steady state is 5 weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if you are going up because the scale stalled for two weeks, wait. two weeks is noise