if you are asking whether to go up, the fact you are asking usually means not yet, i think
#dosing-titration 2025-11-25
Tuesday18 messages4 participantstimes are UTC
Highlights from this day
- provincial_pat — plateau versus set point is not answerable in under six months of data 20:01
- provincial_pat — holding is not failing. most people here who lasted two years held at least one dose for months 20:19
- thirty_min_wait — i went from 2.5 to 5 and honestly could not tell the difference in appetite 20:38
- spreadsheet_stu — the honest answer is that most of us are running protocols nobody has ever studied 21:21
- spreadsheet_stu — if i hold at 10 indefinitely am i losing anything 21:24
do you tell your prescriber you held or do you just hold
how much does the last dose still matter 5 days later
is there any actual reason to escalate every 4 weeks other than the trial did it
the ladder in the trials is a starting point, not a schedule you owe anyone
with a roughly seven day half-life you are near steady state after about five weeks at a dose
plateau versus set point is not answerable in under six months of data
[edited]⚠️10🧪7
holding is not failing. most people here who lasted two years held at least one dose for months
📈10
my titration ladder took 25 months to climb and i would do it slower again
small steps are better than big ones and the only reason people take big ones is impatience
nobody here can tell you what dose to be on and the ones who try get corrected
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i went from 2.5 to 5 and honestly could not tell the difference in appetite
✅2📈1
thats anecdote
the honest answer is that most of us are running protocols nobody has ever studied
😂15
if i hold at 10 indefinitely am i losing anything
✅4📈18🧪7
n of 1
whats the smallest step anyone has managed between doses