is it normal for appetite to come back at the end of the week
#dosing-titration 2025-11-11
Tuesday57 messages11 participantstimes are UTC
Highlights from this day
- invoice_mismatch — stepping back down on purpose is a completely reasonable move and this channel should say so more often 12:32
- hot_mailbox — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess if the current dose is still working, going up is… 13:01
- bolus_bo — how do you decide between holding and stepping when both feel wrong 13:26
- reta_resting_hr — do you tell your prescriber you held or do you just hold 14:00
- low_and_slow — what does the room think about jumping a rung to catch up 17:10
held for months
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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two weeks is nothing
small steps are better than big ones and the only reason people take big ones is impatience, ill dig out the number
coming down from 7.5 to 1.7, how bad is the appetite rebound
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
if the current dose is still working, going up is spending headroom you might want later
appetite returning at the end of the week is extremely common and is not the dose failing, thats just me
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
ok so nobody here can tell you what dose to be on and the ones who try get corrected, n of 1 obviously
no trial for that
i would hold
if i hold at 2 indefinitely am i losing anything
how do you decide between holding and stepping when both feel wrong
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i have been at 7.5 for 18 months and honestly i have stopped wanting to move
the trials escalated on a fixed schedule because a trial has to. you are not a trial
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
n of 1
do you tell your prescriber you held or do you just hold
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i hold for two months minimum before i decide a dose has stopped doing anything
i escalate on symptoms. if the current dose is still doing something i stay on it
i escalate on symptoms. if the current dose is still doing something i stay on it
whats the smallest step anyone has managed between doses
has anyone gone up and then straight back down and been glad they tried
came down from a treatment dose to maintenance over about three months and it was uneventful
right so whats a sensible maintenance dose after a year at treatment dose
came down, no regrets
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
anyone here split their weekly into two and would they do it again
do you escalate on the calendar or on how you feel
the people who do best here are almost always the ones going slowest
sorry to jump in how much does the last dose still matter 8 days later
if it "stopped working after four days" that is almost never pharmacokinetics
update from 11 months ago: held at the same dose the whole time and still losing slowly
thats noise
how do you tell a plateau from just being at your set point
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, take that with a pinch of salt
if you are asking whether to go up, the fact you are asking usually means not yet
*Medutest not the other one
whats the longest anyone has stayed on one dose
do you count from injection day or from when you actually felt it
split dosing has no trial behind it. people here do it and report on it, thats all
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
right so holding is not failing. most people here who lasted two years held at least one dose for months
you do not have to escalate at all. that is a real option that gets forgotten
is there any actual reason to escalate every 4 weeks other than the trial did it
go slower
not advice
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if i took it 8 days late do i shift the schedule or go back to the old day
holding is not failing. most people here who lasted two years held at least one dose for months
what does the room think about jumping a rung to catch up
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plateau versus set point is not answerable in under six months of data
is there a trial anywhere that studied twice weekly, or is it all anecdote
steady state is 5 weeks
coming back to this the ladder in the trials is a starting point, not a schedule you owe anyone
with a roughly seven day half-life you are near steady state after about five weeks at a dose
how long did you hold at 10 before you moved up
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
my titration ladder took 8 months to climb and i would do it slower again
the honest answer is that most of us are running protocols nobody has ever studied