appetite returning at the end of the week is extremely common and is not the dose failing
stepping back down on purpose is a completely reasonable move and this channel should say so more often
#dosing-titration 2025-09-28
Sunday19 messages3 participantstimes are UTC
Highlights from this day
- residual_solvent — with a roughly seven day half-life you are near steady state after about five weeks at a dose 12:55
- closer_not_simpler — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, still working it out 13:03
- closer_not_simpler — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 14:38
- residual_solvent — do you count from injection day or from when you actually felt it 15:29
unrelated but is there a point where going up stops buying you anything
how much does the last dose still matter 8 days later
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
update from 4 months ago: held at the same dose the whole time and still losing slowly
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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for the archive if it "stopped working after four days" that is almost never pharmacokinetics
is there any actual reason to escalate every 4 weeks other than the trial did it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, still working it out
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)small steps are better than big ones and the only reason people take big ones is impatience
came down, no regrets
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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genuine question do you tell your prescriber you held or do you just hold
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i went from 5 to 12 and honestly could not tell the difference in appetite
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
if you are asking whether to go up, the fact you are asking usually means not yet
do you count from injection day or from when you actually felt it
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the people who do best here are almost always the ones going slowest
whats your rule for when a side effect means hold rather than push